Примери за използване на Products that induce на Английски и техните преводи на Български
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Medicinal products that induce CYP3A4/5.
Medicinal products that induce CYP3A activity would be expected to increase the clearance of darunavir and ritonavir, resulting in lowered plasma concentrations of darunavir and ritonavir(e.g. rifampicin, St John's wort, lopinavir).
Co-administration of REYATAZ and medicinal products that induce CYP3A4 is not recommended(see sections 4.3 and 4.5).
Medicinal products that induce CYP3A4, CYP2C9 or CYP2C19 may increase the clearance of etravirine, resulting in lowered plasma concentrations of etravirine.
Elvitegravir is primarily metabolised by CYP3A,and medicinal products that induce or inhibit CYP3A may affect the exposure of elvitegravir.
Medicinal products that induce or inhibit CYP3A may thus affect the clearance of rilpivirine(see section 5.2).
Coadministration with medicinal products that induce 3A4 activity may reduce the efficacy of Instanyl.
Medicinal products that induce or inhibit CYP3A may thus affect the clearance of rilpivirine(see section 5.2).
Coadministration with medicinal products that induce 3A4 activity may reduce the efficacy of PecFent.
Medicinal products that induce those enzymes or transporters may decrease dolutegravir plasma concentration and reduce the therapeutic effect of dolutegravir.
Coadministration of telaprevir and medicinal products that induce CYP3A and/or P-gp may decrease telaprevir plasma concentrations.
Medicinal products that induce CYP3A activity would be expected to increase the clearance of darunavir and ritonavir, resulting in lowered plasma concentrations of these compounds and consequently that of darunavir, leading to loss of therapeutic effect and possible development of resistance(see sections 4.3 and 4.4).
Doravirine is primarily metabolised by CYP3A,and medicinal products that induce or inhibit CYP3A are expected to affect the clearance of doravirine(see section 5.2).
Medicinal products that induce those enzymes or transporters may decrease dolutegravir plasma concentration and reduce the therapeutic effect of dolutegravir(see Table 1).
Doravirine is primarily metabolised by CYP3A,and medicinal products that induce or inhibit CYP3A are expected to affect the clearance of doravirine(see section 5.2).
Other medicinal products that induce CYP3A4 activity(e.g. dexamethasone, phenytoin, carbamazepine, phenobarbital or herbal preparations containing Hypericum perforatum, also known as St. John's Wort) may also increase metabolism and decrease dasatinib plasma concentrations.
Co-administration of INCIVO and medicinal products that induce CYP3A and/or P-gp may markedly decrease telaprevir plasma concentrations.
Co-administration of EVOTAZ and medicinal products that induce CYP3A4 is contraindicated or not recommended(see sections 4.3 and 4.5) because, in addition to decreased plasma concentrations of atazanavir due to induction of CYP3A4, decreased plasma concentrations of cobicistat could result in cobicistat plasma levels that are insufficient to achieve adequate pharmacoenhancement of atazanavir.
Co-administration of CELSENTRI with medicinal products that induce CYP3A4 may decrease maraviroc concentrations and reduce its therapeutic effects.
Medicinal products that induce CYP3A4 or CYP2C8.
Co-administration of bedaquiline and medicinal products that induce CYP3A4 may decrease bedaquiline plasma concentrations and reduce its therapeutic effect.
Concomitant medicinal products that induce CYP3A4(e.g. phenytoin, carbamazepine, rifampicin, barbiturates or St John's wort, Hypericum perforatum) should be avoided.
Co-administration of rilpivirine and medicinal products that induce CYP3A has been observed to decrease the plasma concentrations of rilpivirine, which could reduce the therapeutic effect of rilpivirine.
The concomitant administration of other medicinal products that induce CYP3A4(e.g., phenytoin, carbamazepine, phenobarbital and St. John's Wort) is likewise likely to reduce exposure to nilotinib to a clinically relevant extent.
Caution should be used when co-administering medicinal products that induce CYP3A or potentially toxic medicinal products which are themselves metabolised by CYP3A(see section 4.3 and below).
Medicinal products inducing orthostatic hypotension Medicinal products that induce postural hypotension(nitrates derivatives, type 5-phosphodiesterase inhibitors, tricyclic antidepressants, antipsychotics, dopaminergic agonists, levodopa, amifostine, baclofen…) may add their effects to that of beta-blockers.
A woman on short-term treatment with medicinal products that induce hepatic drug metabolising enzymes or individual active substances that induce these enzymes should temporarily use a barrier method in addition to EVRA, i.e. during the time of concomitant medicinal product administration and for 28 days after their discontinuation.