Примери за използване на Toremifene на Английски и техните преводи на Български
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The active substance is toremifene;
Cancer(such as toremifene and vandetanib).
Toremifene(used to treat breast cancer).
Cancer(e.g. toremifene, vandetanib).
The active ingredient of Fareston is toremifene citrate.
Toremifene is a nonsteroidal triphenylethylene derivative.
The active substance in Fareston, toremifene, is an anti-oestrogen.
Toremifene is recommended for postmenopausal patients.
Fareston is a medicine that contains the active substance toremifene.
Fareston(toremifene)- Summary of product characteristics- L02BA02.
Certain medicinal products used in cancer(e.g. toremifene, vandetanib).
Fareston(toremifene)- Conditions or restrictions regarding supply and use- L02BA02.
Concomitant use of those drugs with toremifene should be carefully considered.
Toremifene binds extensively(> 99.5%) to serum proteins, mainly to albumin.
Therefore, the concomitant use of toremifene with such drugs should be avoided.
The reactions are usually mild andmostly due to the hormonal action of toremifene.
Toremifene should be used cautiously in patients with liver impairment(see section 5.2).
Endometrial hypertrophy may develop during the treatment due to the partial estrogenic effect of toremifene.
The acute toxicity of toremifene is low with LD-50 in rats and mice of more than 2000 mg/kg.
With Phenobarbital, carbamazepine(due to the probability of a decrease in the level of toremifene in the bloodstream);
In some experimental cancers and/or using high-dose, toremifene displays anti-tumour effects which are not estrogen-dependent.
With ketoconazole, antimycotics,macrolide antibiotics(due to inhibition of the metabolic processes of toremifene).
It is bound to plasma proteins even more extensively than toremifene, the protein bound fraction being> 99.9%.
A few cases of hypercalcaemia have been reported in patients with bone metastases at the beginning of toremifene treatment.
Should be noted that all triphenylethylene compounds(toremifene citrate, tamoxifen citrate, clomiphene citrate), has estrogen effects in the liver.
Pre-existing endometrial hyperplasia andsevere hepatic failure are contra-indications in long- term use of toremifene.
Enzyme complex, known to be responsible for the metabolism of toremifene in humans, is cytochrome P450-dependent hepatic mixed function oxidase.
The main thing is not to forget that Testosterone Propionate cycle requires treatment with Clomiphene Citrate or Toremifene Citrate.
For toremifene, flucloxacillin and fusidic acid displacement interactions could not be excluded(no clinically relevant capturing interactions are expected).
Combinations contraindicated(see section 4.3): Cisapride,erythromycin intravenous(IV), toremifene, mizolastine, moxifloxacin, arsenic, Class IA and III antiarrhythmics.