Eksempler på brug af Ames test på Engelsk og deres oversættelser til Dansk
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Phenoxyethanol has shown not to be mutagenic in the Ames test.
In one single genotoxicity study(Ames test), no mutagenic effect has been observed.
CEPROTIN proved to have no mutagenic potential in the Ames test performed.
Sorafenib was not genotoxic in the Ames test or in the in vivo mouse micronucleus assay.
The Ames test(with or without activation), and a dominant lethal assay in male mice were negative.
BHT does not show mutagenic properties- Ames test is negative OECD SIDS, 2002; IUCLID, 2000e.
Ames test results in four strains of S. typhimurium, with and without metabolic activation, were negative.
However, it did not induce mutagenicity in the Ames test or the CHO/ HGPRT gene mutation assay.
Pemetrexed was not mutagenic in either the in vitro chromosome aberration test in Chinese hamster ovary cells, or the Ames test.
Some phthalates are not mutagenic(Ames test) and this also applies DIBP IUCLID, 2000f; Jensen AA, 1997d.
Results indicate that sodium phenylbutyrate did not induce any mutagenic effects in the Ames test with or without metabolic activation.
Heptanone has shown negative result in Ames test and other tests for mutagenic properties have also been negative.
One intermediate in the manufacturing process, which is also present in the final drug substance(< 0.15%),was positive for mutagenesis in an in vitro bacterial cell assay Ames test.
Genotoxicity Ethylene dimethacrylate was not mutagenic in Ames test(S. typhimurium) with or without activation 26.
P- Xylene is tested negative in Ames test as well as in a number of other short-term tests for mutagenic effects IUCLID, 2000j; Jensen AA, 2003b.
Carbaglu showed no significant mutagenic activity in a battery of genotoxicity tests performed in vitro(Ames test, human lymphocyte metaphase analysis) and in vivo micronucleus test in rat.
Tert-Butyl alcohol is found inactive in Ames test as well as in many other short-term tests and thus it has no mutagenic properties Jensen AA, 2003a; IUCLID, 2000i.
Mutagenicity and genotoxicity studies, with and without metabolic activation where appropriate,have shown that saquinavir has no mutagenic activity in vitro in either bacterial(Ames test) or mammalian cells Chinese hamster lung V79/HPRT test. .
Puregon showed no mutagenic potential in the Ames test or in the in vitro chromosome aberration test with human lymphocytes.
Exposure to p-xylene in a concentration which affected the female animal generated an increased foetus mortality, an impaired growth and development of the foetus as well as foetus malformations in tests with pregnant mice and rats(ATSDR, 2005; Jensen AA,2003b). p-Xylene is tested negative in Ames test as well as in a number of other short-term tests for mutagenic effects IUCLID, 2000j; Jensen AA, 2003b.
Capecitabine was not mutagenic in vitro to bacteria(Ames test) or mammalian cells Chinese hamster V79/ HPRT gene mutation assay.
Several tests show that Kathon is mutagenic in Ames test whereas there are negative results in studies investigating the DNA damaging potential of Kathon Madsen T et al, 2001.
NOEL for the direct chemical effects was set to 1566 mg/kg bw/day for male mice and 4363 mg/kg bw/day for female mice(IUCLID,2000i). tert-Butyl alcohol is found inactive in Ames test as well as in many other short-term tests and thus it has no mutagenic properties Jensen AA, 2003a; IUCLID, 2000i.
Rotigotine did not induce gene mutations in the Ames test, but did show effects in the in vitro Mouse Lymphoma Assay with metabolic activation and weaker effects without metabolic activation.
Benzyl alcohol has not shown to be mutagenic in the Ames test and other bacterial tests or in cell cultures Jensen AA, 1999; Nair B., 2001; WHO, 2002; NTP, 1989.
Dasatinib was not mutagenic in in vitro bacterial cell assays(Ames test) and was not genotoxic in an in vivo rat micronucleus study.
Genotoxicity Alitretinoin was studied for genotoxic potential using the Ames test, the in vivo mouse micronucleus assay, the chromosomal aberration test in human lymphocytes, and the CHO cell mutation test. .
Paclitaxel has been shown to be genotoxic in vivo(micronucleus test in mice), butit did not induce mutagenicity in the Ames test or the Chinese hamster ovary/ hypoxanthine-guanine phosphoribosyl transferase(CHO/ HGPRT) gene mutation assay.
Chromosomal aberrations_BAR_(bone marrow cells, mouse)_BAR_ host-mediated assay(G46)_BAR_ 1 Ames test j 2 Chromosome breakage_BAR_ 3 SCE(human diploid and_BAR_ Chinese hamster cells)_BAR_ Dominant lethal_BAR_ Micronuclei_BAR_ 4 Gene mutation CHV-79 j.