Eksempler på bruk av Compared with healthy på Engelsk og deres oversettelse til Norsk
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Increased water evaporation is seen in psoriatic skin lesions compared with healthy skin(1).
As expected, fewer football players, compared with healthy young men from a Norwegian population based study(HUNT study, Trøndelag), suffered from hypertension(7% versus 11%).
Cancer cells require extra energy throughout the growth process, andso change their energy consumption compared with healthy cells.
CVD patients had a 30% reduction in EDV anda decrease in LDL cholesterol of 1.2 mmol/L compared with healthy volunteers, suggesting that lycopene supplementation can improve CVD patients.
Renal impairment: end stage renal disease(ESRD) patients receiving dialysis had 2-fold higher duloxetine Cmax andAUC values compared with healthy subjects.
Compared with healthy subjects, the apparent plasma clearance of duloxetine was 79% lower, the apparent terminal half-life was 2.3 times longer, and the AUC was 3.7 times higher in patients with moderate liver disease.
Dexmedetomidine plasma protein binding is decreased in subjects with hepatic impairment compared with healthy subjects.
Drug half-life was however doubled in patients with severe hepatic impairment compared with healthy controls(10.4 days compared to 4.7 days), possibly related to an increased tissue distribution.
In patients with mild hepatic impairment, lomitapide AUC and Cmax were 47% and 4% higher, respectively, compared with healthy volunteers.
Compared with healthy younger volunteers,healthy elderly volunteers(≥65 years) had reduced clearance of sildenafil, resulting in approximately 84% and 107% higher plasma concentrations of sildenafil and its active N-desmethyl metabolite, respectively.
In patients with moderate hepatic impairment, lomitapide AUC and Cmax were 164% and 361% higher, respectively, compared with healthy volunteers.
The pharmacokinetics of daptomycin is not altered in subjects with moderate hepatic impairment(Child-Pugh B classification of hepatic impairment) compared with healthy volunteers matched for gender, age and weight following a single 4 mg/kg dose.
New research suggests that hoarders have unique patterns of brain activity when faced with making decisions about their possessions, compared with healthy people.
The systemic exposures to doripenem and doripenem-M-1 are substantially increased in patients with end stage renal disease receiving haemodialysis compared with healthy subjects.
AUC of the microbiologically inactive ring-opened metabolite(doripenem-M-1)is expected to be considerably increased in patients with severe renal impairment compared with healthy subjects.
Several studies have shown increased levels of autoantibodies directed against brain-derived neurotrophic factor(BDNF)in patients with Landau-Kleffner syndrome compared with healthy controls.
In a study where 12 subjects with end stage renal disease received a single 500 mg dose of doripenem as a 1-hour i.v. infusion,the systemic exposure to doripenem and doripenem-M-1 were increased compared with healthy subjects.
Following administration of a single 50 mg-dose, the AUC0- of eltrombopag was 32% to 36% lower in subjects with mildto moderate renal impairment, and 60% lower in subjects with severe renal impairment compared with healthy volunteers.
Following the administration of a single 50 mg dose, the AUC0- of eltrombopag was 41% higherin subjects with mild hepatic impairment and 80% to 93% higher in subjects with moderate to severe hepatic impairment compared with healthy volunteers.
Due to modest decreases in protein binding of aprepitant in patients with renal disease,the AUC of pharmacologically active unbound aprepitant was not significantly affected in patients with renal impairment compared with healthy subjects.
In a phase I open-label study of single dose gefitinib 250 mg in patients with mild, moderate orsevere hepatic impairment due to cirrhosis(according to Child-Pugh classification), there was an increase in exposure in all groups compared with healthy controls.
After administration of pantoprazole to patients with liver impairment(Child-Pugh classes A, B and C) the half-life values increased to between 3 and 7 h and the AUC values increased by a factor of 3-6,whereas the Cmax only increased slightly by a factor of 1.3 compared with healthy subjects.
In patients with mild hepatic impairment(Child-Pugh A),there was no significant changes in pharmacokinetics compared with normal healthy volunteers.
The pharmacokinetics of perampanel following a single 1 mg dose were evaluated in 12subjects with mild and moderate hepatic impairment(Child-Pugh A and B, respectively) compared with 12 healthy, demographically matched subjects.