Examples of using Does not induce in English and their translations into Finnish
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Aliskiren does not induce CYP3A4.
Raltegravir is not a substrate of cytochrome P450(CYP) enzymes, does not inhibit CYP1A2, CYP2B6, CYP2C8, CYP2C9,CYP2C19, CYP2D6 or CYP3A, and does not induce CYP3A4.
Sufentanil does not induce histamine release.
In addition, ibandronic acid does not inhibit the major human hepatic P450 isoenzymes and does not induce the hepatic cytochrome P450 system in rats.
Fidaxomicin does not induce or inhibit CYP450 enzymes in vitro.
At recommended doses in humans, bupropion does not induce its own metabolism.
Bazedoxifene does not induce or inhibit the activities of major CYP isoenzymes.
In in vitro studies with human hepatocytes, plerixafor does not induce CYP1A2, CYP2B6, and CYP3A4 enzymes.
Melatonin does not induce CYP1A enzymes in vitro at supra-therapeutic concentrations.
Furthermore, ambrisentan does not induce MRP2, Pgp or BSEP.
Gabapentin does not induce hepatic mixed function oxidase enzymes responsible for drug metabolism.
As a consequence of the subunit nature of the vaccine, vaccination does not induce production of antibodies against CSF virus antigen, other than E2.
Lomitapide does not induce CYPs 1A2, 3A4, or 2B6, and does not inhibit CYPs 1A2, 2B6, 2C9, 2C19, 2D6, or 2E1.
An in vitro study of azacitidine with cultured human hepatocytes indicates that at concentrations of 1.0 µM to 100 µM(i.e. up to approximately 30-fold higher than clinically achievable concentrations),azacitidine does not induce CYP 1A2, 2C19, or 3A4 or 3A5.
Since degarelix does not induce a testosterone surge it is not necessary to add an anti-androgen as surge protection at initiation of therapy.
In vitro studies indicate that raltegravir is not a substrate of cytochrome P450(CYP) enzymes, does not inhibit CYP1A2, CYP2B6, CYP2C8, CYP2C9,CYP2C19, CYP2D6 or CYP3A, does not induce CYP3A4 and does not inhibit P-glycoprotein-mediated transport.
Epoetin alfa does not induce bacterial gene mutation(Ames Test), chromosomal aberrations in mammalian cells, micronuclei in mice, or gene mutation at the HGPRT locus.
The purification shall at least ensure that the residual content of non-structural proteins in vaccines reconstituted from such antigen does not induce detectable levels of antibody against non-structural proteins in animals which had received one initial and one subsequent booster vaccination.
Bazedoxifene does not induce or inhibit the activities of major CYP isoenzymes, and is unlikely to interact with co- administered medicinal products via CYP-mediated metabolism.
In vitro, dolutegravir did not induce CYP1A2, CYP2B6 or CYP3A4.
In clinical studies, caspofungin did not induce the CYP3A4 metabolism of other substances.
Ziconotide did not induce bacterial gene mutation and was not genotoxic.
Cabazitaxel did not induce mutations in the bacterial reverse mutation(Ames) test.
Mirabegron did not induce CYP1A2 or CYP3A.
However, it did not induce mutagenicity in the Ames test or the CHO/HGPRT gene mutation assay.
It did not induce a proliferative response in non-haematological tumor cell lines in vitro.
Sunitinib did not induce structural chromosome aberrations in human peripheral blood lymphocyte cells in vitro.
In addition, retigabine and NAMR did not induce CYP1A2 or CYP3A4/5 in human primary hepatocytes.
At all dose levels tested, palonosetron did not induce clinically relevant prolongation of the QTc interval.
Piperaquine did not induce malformation in rats and rabbits.