Examples of using Low affinity in English and their translations into German
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Dinotefuran has low affinity to mammalian acetylcholine receptor sites.
The antibodies that are produced are of low affinity and specificity;
The low affinity of the surface reduces the loss of cells and valuable proteins through binding.
The CD23 molecule is the low affinity IgE receptor found on B cells.
But there are also manycommercially available antibodies showing very low affinity.
Avoiding fat, having a low affinity to fat and a high affinity to water.
As the concentration rises, however, it also regulates genes with a low affinity," Wolf explains the principle.
In contrast, the dimeric form of M2-PK has a low affinity for phosphoenolpyruvate, being nearly inactive at physiological PEP concentrations.
The ability to quickly bind and separate from the matrix isessential when movement is required and the low affinity to ligands enables this.
This finding is consistent with the low affinity of tadalafil for PDE6 compared to PDE5.
Patients with low affinity, on the other hand, displayed a considerably higher level of insulin production, which remained constant over a time frame of 30 months.
This characteristic of Anadrol 50 produces more toxicity to the liver since,more amount of the steroid needs to be taken in order to compensate for its low affinity to the androgen receptors.
An enzyme with a high Km has a low affinity for the substrate, and a high concentration of the substrate is needed in order for the enzyme to become saturated.
Moreover, Clinical interaction studies with nelfinavir, a moderately potent OATP inhibitor,and pravastatin, a low affinity OATP inhibitor, did not result in clinically significant changes in sitaxentan plasma levels.
AA in the tissue compartment with low affinity and high turnover(adrenals, lung, kidneys, testis, eye) is easily replaced by IAA but not in the tissue compartment with high affinity and low turnover brain.
The consequences of these modifications are that IGF-1 LR3 retains the pharmacological activity of IGF-1 as an agonist of the IGF-1 receptor,has very low affinity for the insulin-like growth factor-binding proteins(IGFBPs), and has improved metabolic stability.
Despite low affinity for the A2A adenosine receptor, regadenoson has high potency for increasing coronary conductance in rat and guinea pig isolated hearts, with EC50 values of 6.4 nM and 6.7-18.6 nM, respectively.
A critical role for the ER in calcium signaling was acknowledged before such a role for the mitochondria was widely accepted,in part because the low affinity of Ca2+ channels localized to the outer mitochondrial membrane seemed to fly in the face of this organelle's purported responsiveness to changes in intracellular Ca2+ flux.
Regadenoson is a low affinity agonist(Ki≈ 1.3 µM) for the A2A adenosine receptor, withat least 10- fold lower affinity for the A1 adenosine receptor(Ki> 16.5 µM), and very low, if any, affinity for the A2B and A3 adenosine receptors.
The cholinergic, histamine receptors or adrenal gland can low affinity, bile alkaline resistance, cardiovascular adverse reaction is less than the tricyclic antidepressants.
IGF-2 also binds with a lower affinity to the IGf-1 receptor and insulin receptor.
The peptide itself has a lower affinity for these receptors.
This is due to the fact that it has lower affinity for androgen receptors.
Anadrol 50 has a lower affinity, which may be why we have a 50mg tablet dosage.
Anadrol 50 has a lower affinity, which may be why we have a 50mg tablet dosage.
Peptides representing a very small fraction of the protein of interest are not in the native conformation andoften lead to lower affinity antibodies.
Risperidone binds also to alpha1-adrenergic receptors, and, with lower affinity, to H1-histaminergic and alpha2-adrenergic receptors.
The transport mechanism for crossing the blood/brain barrier is similarly stereospecific,IAA having a lower affinity for the carrier than AA Spector, R. et al, 1974.
The affinity of insulin glargine for the human IGF-1 receptor is approximately 5 to 8-fold greater than that of human insulin(but approximately 70 to 80-fold lower than the one of IGF-1),whereas M1 and M2 bind the IGF-1 receptor with slightly lower affinity compared to human insulin.
