Examples of using Mouse models in English and their translations into German
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We have completed now clinical trials in four mouse models of this disease.
In mouse models of depression, NSI-189 significantly improved behavioral responses associated with depression.
Allergic airway inflammation was assessed in mouse models of acute asthma.
Conclusions: Alzheimer's mouse models could therefore be a useful tool for understanding the pathology of glaucoma and other retinal diseases.
To test various viruses for their dependence on the aggresomeand UPS pathways, using cellular and mouse models.
For that purpose we will study genetic mouse models with glia-selective deletion of glutamate- and purinoceptors.
The preclinical drug discovery strategy will bebased on the newly generated cell lines and mouse models of MCL.
Cellular systems, genetically modified mouse models, and clinical intervention studies are used to discover new signalling pathways and target structures.
The CRC will use a combination of basic research, for example in mouse models, and studies of human patients.
To this end, we use modern methods of cell biology,molecular biology and protein biochemistry as well as transgenic mouse models.
This progress was made possible by combining mouse models, biochemical work and the latest developments in mass spectrometry proteomic analysis.
Topic 3: Dosimetry in medical and health relevant applications,for dose validation in radiotherapy, in mouse models and in radiological emergencies.
Transgenic cell and mouse models showed that the loss of synapses and neurons in Alzheimer's disease correlates with the aggregation of Tau.
He has been involved in identifyingneuronal networks that undergo significant degeneration in mouse models of Down syndrome and Alzheimer's disease.
This group focuses in generating faithful brain tumor mouse models that are necessary to test new treatment options before they can ultimately be given to patients.
We use a wide range of methods in our research- from histology,biochemistry and imaging techniques to behavioral studies on transgenic mouse models.
In this cooperation project(with the group of Prof. Johannes Backs),we generate genetically modified mouse models with specific expression and conditional knock-out in purkinje fibres.
Year 2014 At Helmholtz-Center München, the German Mouse Clinic(GMC I)is established as a German center for the characterisation and phenotyping of mouse models.
We analyze neuro-glia communication signals on the molecular level utilizing transgenic andknockout mouse models in combination with neurodegenerative disease mouse models.
Research data, tissue samples and cell and mouse models will be pooled and managed in the project and be available to all the associated researchers for further scientific experiments.
The most promising agents will be evaluated in sophisticated in vivo imaging assays including multi-parametric PET/MRI and determination of compound efficacy,specificity and distribution in established mouse models and tumor xenografts for leukemia as well as solid cancers.
In mouse models and patient samples, they have demonstrated that the growth regulator mTOR- mammalian target of rapamycin- promotes de novo lipid synthesis and thus tumorigenesis.
This mechanism stays dominant in whole preimplantation development, and mouse models have shown that telomere length can increase by thousands of base-pairs within the initial one or two cell cycles.
Mouse models allow basic insights into the development and the progression of diseases and therefore provide the opportunity to screen for effects of disease triggering genetic defects and innovative therapeutic approaches in the entire organism.
The"Genome Engineering" Unit provides a centralized facility to generate mouse models of neurodegenerative diseases in particular of frontotemporal lobar degeneration(FTLD), amyotrophic lateral sclerosis(ALS) and dementia.
Researchers used mouse models to demonstrate“that both, CB2 selective activation and antagonism have potential efficacy in cancer associated bone disease but further studies are warranted and ongoing.”.
We are searching for possible candidates for such indicators in mouse models, and, at the same time, are establishing a clinical cohort study that will enable us to test such markers in patients with mild cases of Alzheimer's.
The researchers were able to demonstrate on mouse models that the regulatory T cells(Treg) specific T lymphocytes of the beta amyloid peptide control, which accumulates in the brains of Alzheimer patients as possible.
Based on an altered expression profile of TRPC channels in mouse models of metabolic syndrome(NZO) and subacute chronic renal failure(UUO), we plan a detailed characterization of the(modified) Ca2+ signals in these mouse models.
In particular, inflammatory andmetastatic visceral lymph node alterations have been observed in mouse models of cancer harboring breast12,13, pancreatic14, colorectal15 and lung16 tumors, as well as fibrous histocytomas17, and an aged mouse model of acquired hydronephrosis18.