Examples of using Levodopa in English and their translations into Hebrew
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This allows more of the levodopa to reach the brain.
Levodopa is highly effective in controlling most symptoms of Parkinson.
The plasma half-life of levodopa is about 50 minutes, without carbidopa.
Carbidopa may also reduce nausea and vomiting andpermit more rapid titration of levodopa.
In addition, the beneficial effects of levodopa in Parkinson's disease have been reported to be reversed by phenytoin and papaverine.
Carbidopa allows patients treated for Parkinson'sdisease to use much lower doses of levodopa.
But you will probably both feel better if you give him Levodopa and confirm with DNA tests.
Levodopa, an aromatic amino acid, is a white, crystalline compound, slightly soluble in water, with a molecular weight of 197.2.
AZILECT is indicated for the treatment of Parkinson's disease(PD) as monotherapy(without levodopa) or as adjunct therapy(with levodopa).
However, levodopa, the metabolic precursor of dopamine, does cross the blood-brain barrier, and presumably is converted to dopamine in the brain.
The suggested starting dosage for mostpatients taking more than 1500 mg of levodopa is one tablet of PARCOPA® 25/250 three or four times a day.
The addition of carbidopa with levodopa in the form of PARCOPA® reduces the peripheral effects(nausea, vomiting) due to decarboxylation of levodopa;
The patient should be informed thatPARCOPA® is an immediate-release formulation of carbidopa and levodopa that is designed to begin release of ingredients within 30 minutes.
Standard drugs for Parkinson's disease, other than levodopa without a decarboxylase inhibitor, may be used concomitantly while PARCOPA® is being administered, although dosage adjustments may be required.
The AUC of carbidopa was increased in elderly subjects(n= 10, 65 to 76 yr) by 29% compared to young subjects(n= 24, 23 to 64 yr)following IV administration of 50 mg levodopa with carbidopa(50 mg).
Patients who are taking less than 1500 mg of levodopa a day should be started on one tablet of PARCOPA® 25/100 three or four times a day.
The patient should be cautioned not to change the prescribed dosage regimen and not to add any additional antiparkinson medications,including other carbidopa levodopa preparations, without first consulting the physician.
The addition of carbidopa in a 1:10 ratio with levodopa increases the dose at which a significant proportion of mice are expected to die to 3360 mg/kg.
L-DOPA itself mediates neurotrophic factor release by the brain, L-DOPA can be manufactured and in its pure formis sold as a psychoactive drug with the INN levodopa, trade names include Sinemet, Pharmacopa, Atamet, Stalevo, Madopar, and Prolopa.
Other adverse reactions that have been reported with levodopa alone and with various carbidopa and levodopa formulations, and may occur with PARCOPA® are.
Sporadic cases of a symptom complex resembling neuroleptic malignant syndrome(NMS) have been reported in association with dose reductions or withdrawal of certain antiparkinsonian agents such as levodopa, carbidopa levodopa, or carbidopa levodopa extended release.
Other adverse reactions that have been reported with levodopa alone and with various carbidopa levodopa formulations, and may occur with this combination product are.
Because both therapeutic andadverse responses occur more rapidly with PARCOPA® than with levodopa alone, patients should be monitored closely during the dose adjustment period.
Because carbidopa permits more levodopa to reach the brain and more dopamine to be formed, certain adverse CNS effects, e.g., dyskinesias(involuntary movements), may occur at lower dosages and sooner with the combination product than with levodopa alone.
When this combination product is to be given to patients who are being treated with levodopa, levodopa must be discontinued at least twelve hours before therapy with this product is started.
Carbidopa reduces the amount of levodopa required to produce a given response by about 75% and, when administered with levodopa, increases both plasma levels and the plasma half-life of levodopa, and decreases plasma and urinary dopamine and homovanillic acid.
At steady state, the bioavailability of carbidopa from carbidopa and levodopa tablets is approximately 99% relative to the concomitant administration of carbidopa and levodopa.
Other adverse reactions that have been reported with levodopa alone and with various carbidopa-levodopa formulations, and may occur with carbidopa and levodopa tablets are.
This is most likely due to decreased peripheral decarboxylation of levodopa caused by administration of carbidopa rather than by a primary effect of carbidopa on the nervous system.