Examples of using Microsomal in English and their translations into Polish
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Medicine
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Ecclesiastic
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Computer
Dirlotapide is a potent selective inhibitor of the Microsomal Triglyceride transfer Protein MTP.
Immunoblots with adult worm microsomal antigens are species-specific, so a positive reaction indicates the infecting species.
There is a synergy between vitamins E and A during the inhibition of microsomal peroxidation in hepatocytes.
Reduces the concentration of microsomal enzymes, including cytochrome P-450 and Ndemetylazy benzfetaminowej.
The active substance in Yarvitan, mitratapide,works in the gut by blocking a protein the microsomal triglyceride transfer protein.
Data from in vitro studies using human liver microsomal preparations indicate that entacapone inhibits cytochrome P450 2C9 IC50∼ 4 µM.
Several autoantibodies are identified in affected patients,such as antibodies against thyroid microsomal antigens and against TSH receptors.
Data from in vitro studies using human liver microsomal preparations indicate that entacapone inhibits cytochrome P450 2C9 IC50~ 4 µM.
The microsomal ethanol oxidizing system(MEOS) is an alternate pathway of ethanol metabolism that occurs in the smooth endoplasmic reticulum in the oxidation of ethanol to acetaldehyde.
These hepatic findings are consistent with an induction of hepatic microsomal enzymes, an effect which has not been observed in patients receiving Esbriet.
With microsomal enzyme-inducing medicinal products, the barrier method should be used during the time of concomitant administration of these medicinal products and for 28 days after their discontinuation.
Parathyroid hormone is a natural peptide that is not metabolised by, and does not inhibit hepatic microsomal drug-metabolising enzymes e.g. cytochrome P450 isoenzymes.
In vitro studies using human liver microsomal preparations suggest that CYP 1A2 is the principal isozyme involved in the initial oxidative metabolism of riluzole.
Analgin Injection don't combine with barbiturates and phenylbutazone,may decrease hepatic microsomal enzyme activity and prothrombin formation, lead to bleeding exacerbation.
Female mice receiving duloxetine for 2 years had an increased incidence of hepatocellular adenomas and carcinomas at the high dose only(144 mg/kg/day),but these were considered to be secondary to hepatic microsomal enzyme induction.
Mitotane has been reported to accelerate the metabolism of warfarin through hepatic microsomal enzyme induction, leading to an increase in dose requirements for warfarin.
Although sirolimus inhibits human liver microsomal cytochrome P450 CYP2C9, CYP2C19, CYP2D6, and CYP3A4/ 5 in vitro, the active substance is not expected to inhibit the activity of these isozymes in vivo since the sirolimus concentrations necessary to produce inhibition are much higher than those observed in.
Warfarin and coumarin-like anticoagulants:Mitotane has been reported to accelerate the metabolism of warfarin through hepatic microsomal enzyme induction, leading to an increase in dose requirements for warfarin.
Interactions can occur with drugs that induce microsomal enzymes which can result in increased clearance of sex hormones and which may lead to breakthrough bleeding and/or contraceptive failure.
Cabozantinib is a substrate for CYP3A4 metabolism in vitro, as a neutralizing antibody to CYP3A4 inhibited formation of metabolite XL184 N-oxide by>80% in a NADPH-catalyzed human liver microsomal(HLM) incubation; in contrast, neutralizing antibodies to CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C19, CYP2D6 and CYP2E1 had no effect on cabozantinib metabolite formation.
Repeated administration of darunavir to rats caused hepatic microsomal enzyme induction and increased thyroid hormone elimination, which predispose rats, but not humans, to thyroid neoplasms.
Metabolism In vitro studies have demonstrated thatthere is no or limited liver microsomal mediated metabolism of daptomycin in humans and that CYP450 involvement in daptomycin metabolism is minimal.
The identification of thyroid peroxidase(TPO) by Dr. B. Czarnocka as a microsomal antigen is one of the remarkable discovery of not only the Department but also of the whole Polish science.