Examples of using Binds with high affinity in English and their translations into Romanian
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Pasireotide binds with high affinity to four of the five hssts.
Bezlotoxumab is a human monoclonal antitoxin antibody that binds with high affinity to C.
Trastuzumab binds with high affinity and specificity to sub-domain IV, a juxta-membrane region of HER2's extracellular domain.
Panitumumab is a recombinant,fully human IgG2 monoclonal antibody that binds with high affinity and specificity to the human EGFR.
Metribolone binds with high affinity not only to the AR but also to the progesterone receptor(PR), and binds to the glucocorticoid receptor(GR) as well.
In vitro data andstudies in laboratory animals indicate that 99mTc-depreotide binds with high affinity to somatostatin receptor(SSTR) subtypes 2, 3 and 5.
The substance binds with high affinity to the ATP-binding site in such a manner that it is a potent inhibitor of wild-type BCR-ABL and maintains activity against 32/33 imatinib-resistant mutant forms of BCR-ABL.
Alirocumab is a fully human IgG1 monoclonal antibody that binds with high affinity and specificity to proprotein convertase subtilisin kexin type 9(PCSK9).
Canakinumab binds with high affinity specifically to human IL-1 beta and neutralises the biological activity of human IL-1 beta by blocking its interaction with IL-1 receptors, thereby preventing IL-1 beta-induced gene activation and the production of inflammatory mediators.
Infliximab is a chimeric human-murine monoclonal antibody that binds with high affinity to both soluble and transmembrane forms of TNFα but not to lymphotoxin α(TNFβ).
Varenicline binds with high affinity and selectivity at the α 4β 2 neuronal nicotinic acetylcholine receptors, where it acts as a partial agonist- a compound that has both agonist activity, with lower intrinsic efficacy than nicotine, and antagonist activities in the presence of nicotine.
Mechanism of action Ustekinumab is a fully human IgG1κ monoclonal antibody that binds with high affinity and specificity to the p40 protein subunit of the human cytokines IL-12 and IL-23.
Studies in animals have shown that ioflupane binds with high affinity to the presynaptic dopamine transporter and so radiolabelled ioflupane(123I) can be used as a surrogate marker to examine the integrity of the dopaminergic nigrostriatal neurons.
Ixekizumab is an IgG4 monoclonal antibody that binds with high affinity(< 3 pM) and specificity to interleukin 17A(both IL-17A and IL-17A/F).
Denosumab is a human monoclonal antibody(IgG2) that targets and binds with high affinity and specificity to RANKL, preventing the RANKL/RANK interaction from occurring and resulting in reduced osteoclast numbers and function, thereby decreasing bone resorption and cancer-induced bone destruction.
Denosumab is a human monoclonal antibody(IgG2) that targets and binds with high affinity and specificity to RANKL, preventing activation of its receptor, RANK, on the surface of osteoclast precursors and osteoclasts.
Necitumumab is a recombinant human IgG1 monoclonal antibody that binds with high affinity and specificity to the human epidermal growth factor receptor 1(EGFR) and blocks the ligand binding site, blocking activation by all known ligands and inhibiting relevant biological consequences in vitro.
Migalastat is a pharmacological chaperone that is designed to selectively and reversibly bind with high affinity to the active sites of certain mutant forms of α-Gal A, the genotypes of which are referred to as amenable mutations.
It is a tridentate ligand that binds iron with high affinity in a 2:1 ratio.
It is a tridentate ligand that binds iron with high affinity in a 2:1 ratio.