Examples of using Immunogenicity in English and their translations into Russian
{-}
-
Official
-
Colloquial
No variation in immunogenicity of plasma proteins.
Immunogenicity as a key issue for biotechnology-derived products.
AAV6, a hybrid of AAV1 and AAV2,also shows lower immunogenicity than AAV2.
The immunogenicity of iPSCs should be considered renewedly.
There are no significant differences between the two types of vaccine with regard to safety, immunogenicity, or efficacy.
Immunogenicity of industrial vaccines against illness of Newcastle was studied on 7 poultry farms.
Nevertheless, the use of Annexin V in vivo presents such difficulties as slow pharmacokinetics and high immunogenicity.
Despite the immunogenicity of peptide vaccines is higher than of whole cell ones, it is still rather low.
The application of cytokine-induced TILs demonstrated a positive effect in the treatment of metastatic melanoma- a tumor exhibiting high immunogenicity compared to other malignancies 103.
Immunogenicity of the vaccine from strains b. abortus 19 and 82, b. suis 61 for reindeer in different methods of administration аву 8-2014.
The main disadvantages of poxviruses are high immunogenicity, short-term expression and difficulties in replication in eukaryotic cells.
Immunogenicity of the vaccine from strains B. abortus 19 and 82, B. suis 61 for reindeer in different methods of administration// Agrarian Bulletin of the Urals.
Before licensure, vaccines undergo extensive testing andreview for safety, immunogenicity and efficacy in the laboratory, in animals and in three phases of clinical trials in human subjects.
Abstract: Immunogenicity for laboratory animals(rabbits and mice) of the whole hepatitis C virus envelope proteins and their conserved as well as hypervariable HVR1 sites has been investigated.
The revealed shift of the lipid A type spectrum towards hypoacylated forms is obviously connected with the necessity of immunogenicity decrease and the possibility to avoid immunologic protection of the host organism.
Some mechanisms for increased immunogenicity in iPSCs were proposed too by the study, such as abnormal overexpression of some genes.
Viruses are altered to avoid the shortcomings of typical viral vectors,which may have limited loading capacity, immunogenicity, genotoxicity, and fail to support long-term adequate transgenic expression.
Heat shock protein is needed to enhance immunogenicity of a recombinant antigen by activating antigen-presenting cells and participation in antigen processing 6.
They speculated that the effect was related to its antioxidant action on the initial ischemia/reperfusion injury of the renal allograft,thereby reducing the immunogenicity of the allograft and the"grateful dead" or stressed cells.
To overcome insufficient immunogenicity of other tumors, some researchers tried to modify autologous circulating Т lymphocytes providing them with Т cell receptors(TCR), which with high specificity to cancer antigen.
The main properties of separation viral vectors such as dimensions of viral particles, the size of genome andinsert capacity, immunogenicity, transduction efficiency and virus expression in the target cells are presented in the Table.
They comment:“Data on immunogenicity of vaccines in the immunocompromised host are scarce and the small samples in each category give little power for comparisons between age classes or vaccine schemes.”.
A key disadvantage of the technique is the instability of non-resorbable matrix combined with high immunogenicity of xenomaterial: decellularized vascular grafts are proved to provoke acute and chronic inflammation 91, 92.
The Influenza Genome Sequencing Project is creating a library of influenza sequences that will help us understand what makes one strain more lethal than another,what genetic determinants most affect immunogenicity, and how the virus evolves over time.
The second stage, studying of indicators of a reactogenicity and immunogenicity of a vaccine for children, in comparison with the foreign analogue registered in the Russian Federation, confirmed safety and high immunological efficiency of the vaccine being studied.
Microorganisms are known to develop various mechanisms of molecular transformation of the cell membrane main components,capable to alter immunogenicity of PAMP, which is an important strategy in the ability to avoid or modulate the immune response of the host organism 28, 32, 35, 36.
To enhance immunogenicity of whole cell vaccines, preliminary contamination of tumor cells before radiation is possible including that by recombinant viral vectors expressing co-stimulating molecules, or the combined administration of inactivated tumor material with infectious agents, which could play a role of an immune adjuvant 43.
These mainly include the optimal origin of progenitor stem cells(EpiSPCs, MSCs, EPCs, and/or other origins), extracellular matrix components,potential immunogenicity, ideal in vitro culture condition, and other implantation-related dosage, order, route, function monitoring system 59,60.
One of the disadvantages of tumor cell-based vaccines is their low immunogenicity against proper cancer antigens, since tumor tissue contains only a small number of antigens associated with malignant growth, which are significantly exceeded by antigens' amounts and variety expressed in the normal cells.
Recombinant adeno-associated viruses are one of the most perspective delivery vectors for gene therapy and neurobiology owing to their nonpathogenic properties,low immunogenicity on the part of a host, tropism towards the majority of the cells and tissues, high transduction efficiency and long duration of expression 45.