Examples of using Decrease in clearance in English and their translations into Slovenian
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Triazolam: decrease in clearance and increase the pharmacological action of triazolam.
Co-administration with valproic acid was associated with a small butstatistically significant decrease in clearance of TMZ.
This is due to a decrease in clearance in L-dopa resulting in a prolongation of the terminal elimination half-life(t1/ 2) of levodopa.
Co-administration with valproic acid was associated with a small butstatistically significant decrease in clearance of TMZ.
Accordingly, the decrease in clearance is most likely explained by a decrease in renal function in this population.
Concomitant administration of 30 mg esomeprazole resulted in a 45% decrease in clearance of the CYP2C19 substrate diazepam.
The latter includes a sports suspension with a decrease in clearance of 10 mm, an aerodynamic body kit, a revised grille, chrome exhaust pipes, sports seats, aluminum trim inside, slightly modified appliances, 17-inch wheels and brand nameplates.
Moderate renal impairment had a 3-foldincrease in half-life and 70% decrease in clearance compared to healthy volunteers.
Following an intravenous administration of agalsidase beta to adults at doses of 0.3 mg, 1 mg and 3 mg/ kg body weight, the AUC values increased more than dose proportional,due to a decrease in clearance, indicating a saturated clearance. .
A dose-dependency has been observed as indicated by a decrease in clearance and an increase in half-life at increasing doses.
Regarding the dosing by age group, the MAH defended the same dosing for age group 12 to 18 as in adults because theincrease in body weight is compensated by a decrease in clearance, allowing for an equivalent systemic exposure.
The population pharmacokineticanalysis showed an effect of age with a 27% decrease in clearance in the elderly people(above 65 years of age).
Pharmacokinetic parameters were not substantially different from healthy volunteers,other than a decrease in clearance of approximately 30% in comparison with data from a study with healthy volunteers.
Concomitant administration of tigecycline and warfarin(25 mg single-dose)to healthy subjects resulted in a decrease in clearance of R-warfarin and S-warfarin by 40% and 23%, and an increase in AUC by 68% and 29%, respectively.
The decrease in non-renal clearance in the patients of the study was estimated to give a 20% increase in the AUC of lacosamide.
In a population pharmacokinetic study, a 47% decrease in lean body massadjusted creatinine clearance resulted in a 17% decrease in raloxifene clearance and a 15% decrease in the clearance of raloxifene conjugates.
Reduced clearance of ceftazidime was observed in elderly patients,which was primarily due to age- related decrease in renal clearance of ceftazidime.
This is due to a decrease in levodopa clearance resulting in a prolongation of its terminal elimination half-life(t1/2¡).
In patients with impaired moderate liver function, a decrease in the clearance of drospirenone by half compared with healthy women was detected.
In a population pharmacokinetic study, a 47% decrease in lean body massadjusted creatinine clearance resulted in a 17% decrease in raloxifene clearance and a 15% decrease in the clearance of raloxifene conjugates.
A corresponding decrease in creatinine clearance was seen in the hepatic failure population.
The decrease in cetirizine clearance in these elderly volunteers appeared to be related to their decreased renal function.
They are caused by squeezing a part of the urethra,called the prostatic section, and a decrease in its clearance.
When paclitaxel was given after cisplatin,patients showed a more profound myelosuppression and an approximately 20% decrease in paclitaxel clearance.
A decrease in creatinine clearance down to 20 ml/ min may be associated with up to a 2.3-fold increase in pegaptanib AUC.