Examples of using Thalidomide in English and their translations into Ukrainian
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The System for Thalidomide Education and Prescribing Safety.
The reaction of a number of recurrent defy treatment with thalidomide.
Like thalidomide, statin drugs are a class X drug with regard to pregnancy.
MEPs call for better access to compensation for Thalidomide victims.
Thalidomide is not used to treat women of childbearing age.
For the treatment of multiple myeloma, thalidomide is often combined with melphalan and prednisone or dexamethasone.
Thalidomide(Immunoprin) and its derivatives lenalidomide(Revlimid) and pomalidomide(Pomalyst, Imnovid) are also active against TNF.
The mechanisms of action of many drugs including paracetamol, lithium, thalidomide and ketamine[6] are not completely understood.
The horrors of the thalidomide drug disaster resulted from this problem of chirality.
Merrell Company of Cincinnati(which was trying to get the drug approved in the US)provide more information about thalidomide.
Kelsey felt the application for thalidomide contained incomplete and insufficient data on its safety and effectiveness.
Also thalidomide is an immunomodulatory agent that interferes with the growth process and the dividing plasmacytoma cells.
Commonly used induction regimens include dexamethasone with or without thalidomide, and VAD(vincristine, doxorubicin(Adriamycin), and dexamethasone).
Thalidomide, for example, showed no harmful effects in rats, yet showed fetal abnormalities in rabbits, mice, and humans.10.
Within three years, thousands of women who took thalidomide during pregnancy birthed over 10,000 children with shortened or even absent limbs.
The thalidomide tragedy made many countries revise the existing practice of licensing drugs and tighten requirements for licensed drugs.
Because of its known adverse effects on fetal development, the dispensing of thalidomide is regulated by the System for Thalidomide Education and Prescribing Safety(S.T.E.P.S.) program.
Given the thalidomide birth defect disaster of the 1960s, why was it later approved by the U.S. FDA for treatment of leprosy(1996) and of multiple myeloma(2006)?
Exposure to certain medications(such as the anti seizure drug phenytoin, thalidomide, and chemotherapy drugs) during the first trimester of pregnancy may play a role in causing heart defects.
Thalidomide is absolutely contraindicated in women of childbearing age because of its teratogenicity, However, the rest of the contingent of leprosy patients it does not cause significant side reactions.
Program, designed by Celgene pharmaceuticals and carried out in pharmacies where thalidomide prescriptions are filled, educates all patients who receive thalidomide about potential risks associated with the drug.
The Thalidomide Children's Trust was founded on the 10th of August 1973, with the object of providing support to those people who had disabilities caused because their mothers had taken the drug thalidomide during pregnancy.
The Bureau was established in 2010 by former Sunday Times reporter Elaine Potter,who worked on exposing the Thalidomide scandal, and her husband David Potter, who founded software company Psion.
On the other hand drugs like thalidomide with proven fetal risks that outweigh all benefits are classified as Category X.[62].
Thalidomide may also potentially aggravate existing neuropathy and should therefore not be used in patients with clinical signs or symptoms of peripheral neuropathy unless the clinical benefits outweigh the risks.
A German newspaper soon reported 161 babies were adversely affected by thalidomide, leading the makers of the drug- who had ignored reports of the birth defects associated with the it- to finally stop distribution within Germany.
The“clinical trials” of thalidomide involved distributing more than two and a half million tablets of thalidomide to approximately 20,000 patients across the nation- approximately 3,760 women of childbearing age, at least 207 of whom were pregnant.
Their project tracks the number ofpatients who get a blood clot after receiving thalidomide, whether or not the patient received an anticoagulant drug, which are used to help prevent clotting, and if so, which drug was used.
A pregnant woman who takes Thalidomide between the 4th and 7th week of her pregnancy has a 20 percent or greater risk of producing a baby that is missing significant body parts.
People are 60 times more sensitive to thalidomide, a sedative prescribed to pregnant women than mice, 100 times more sensitive than rats, 200 times than dogs, and 700 times than hamstersRolston.
