Examples of using Procainamide in English and their translations into Vietnamese
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With cytostatics, procainamide, allopurinol- to leukopenia.
Procainamide slows the conduction velocity and increases the refractory period, such that the maximal rate of depolarization is reduced.[1].
In a stable patient amiodarone or procainamide would be reasonable.
Taking procainamide enhances the anticholinergic effect of this drug.
Definition ChEBI: A hydrochloride which has procainamide as the amino component.
Theophylline, procainamide: their concentration in blood plasma changes.
Many diseases and drugs(e.g., quinidine, methyldopa, and procainamide) can lead to production of these antibodies.
Procainamide, quinidine and other drugs that cause lengthening of the QT interval- the risk of significant lengthening of the QT interval;
Many diseases and drugs(quinidine, methyldopa, and procainamide) can lead to production of these antibodies.
Procainamide(Procan-SR, Pronestyl) and quinidine(Quinidex, Quinaglute) concentrations increase by 30%-50% during the first week of amiodarone therapy.
However, certain drugs, including birth control pills, procainamide, and thiazide diurectics, affect the accuracy of this test.
It was found that procainamide was effective for treating ventricular arrhythmias, but it had the same toxicity profile as quinidine and it could cause systemic lupus erythematosus like syndrome.
Other forms of lupus include cutaneous lupus erythematosus, which is limited to the skin, and drug-induced lupus erythematosus, which can be triggered by certain prescription drugs,including hydralazine and procainamide.
Class 1A antiarrhythmics such as disopyramide, procainamide, quinidine and class III antiarrhythmics such as amiodarone, dofetilide, sotalo;
In general, these are drugs that have one or more pharmacologic activities similar to bepridil hydrochloride,including anti-arrhythmic agents such as quinidine and procainamide, cardiac glycosides and tricyclic anti-depressants.
With the simultaneous use of caposide with procainamide and drugs that block tubular secretion, the risk of an immunosuppressive effect increases.
There is a close line between the plasma concentrations of the therapeutic and toxic effect, therefore a high risk for toxicity.[1]Many symptoms resemble systemic lupus erythematosus because procainamide reactivates hydroxylamine and nitroso metabolites, which bind to histone proteins and are toxic to lymphocytes.
With the simultaneous use of Capoten with procainamide and allopurinol may develop Stevens-Johnson syndrome and/ or neutropenia, with immunosuppressants- the risk of hematological disorders increases.
These metabolites could then bind to their cell membranes andcause a release of autoantibodies which would react with the neutrophils.[12] Procainamide hydroxylamine has more cytotoxicity by hindering the response of lymphocytes to T-cell and B-cell mitogens.
Procainamide could initiate leukopenia and/or agranulocytosis, which are serious hematologic disorders, and is also known for causing gastrointestinal disturbances and aggravating pre-existing abnormalities in impulse initiation and propagation.[1].
Medications: Long-term use of certain medications, such as hydralazine(Apresoline), procainamide(Procanbid), and quinidine, have been linked with causing a form of lupus known as drug-induced lupus erythematosus.
Procainamide was approved by the US FDA on June 2, 1950, under the brand name"Pronestyl".[22] It was launched by Bristol-Myers Squibb in 1951.[23] Due to the loss of Indonesia in World War II, the source for cinchona alkaloids, a precursor of quinidine, was reduced.
Medicines: The long-term use of certain medications,such as hydralazine(Apresoline), procainamide(Procanbid) and quinidine, has been linked to the cause of a form of lupus known as drug-induced lupus erythematosus.
Procainamide is used for treating ventricular arrhythmias: ventricular ectopy and tachycardia and supraventricular arrhythmias: atrial fibrillation, and re-entrant and automatic supraventricular tachycardia.[3] For example, it can be used to convert new-onset atrial fibrillation, though it is suboptimal for this purpose.[4].
If Lidocaine is usedsimultaneously with class IA antiarrhythmic drugs(disopyramide, procainamide, quinidine), the QT interval is lengthened, in rare cases, ventricular fibrillation or AV blockade may develop.
It was found that procainamide was effective for treating ventricular arrhythmias, but it had the same toxicity profile as quinidine, and it could cause systemic lupus erythematosus-like syndrome.[24][26] These negative characteristics slowed down the search for new antiarrhythmics based on the chemical structure of procainamide.
In addition to blocking the INa current,it inhibits the IKr rectifier K+ current.[1] Procainamide is also known to induce a voltage-dependent open channel block on the batrachotoxin(BTX)-activated sodium channels in cardiomyocytes.[2].
Especially careful monitoring of laboratory parameters and blood pressure is necessary for older people(over 65), patients with renal insufficiency, impaired water and electrolyte balance, arterial hypertension characterized by severe course(including renal genesis), decompensated chronic heart failure, and also to patients taking immunosuppressants, lithium salts,allopurinol or procainamide.
With extreme caution,captopril is prescribed to patients receiving immunosuppressants, procainamide or allopurinol, especially if they have impaired renal function, as well as in patients with systemic vasculitis and diffuse connective tissue diseases.
Both propoxyphene and norpropoxyphene are potent blockers of cardiac membrane sodium channels, and are more potent than lidocaine,quinidine, and procainamide in this respect.[16] As a result, propoxyphene and norpropoxyphene appear to have the characteristics of a Vaughn-Williams Class Ic antiarrhythmic.