Voorbeelden van het gebruik van Increase in cmax in het Engels en hun vertalingen in het Nederlands
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The increase in Cmax is not considered clinically relevant.
Steady state of plasma levels is obtained after 3 to 4 days with a 1.3-fold increase in Cmax and AUC.
There was a supra-proportional increase in Cmax and AUC parameters for doses from 10 mg to 300 mg.
A decreased body weight by 30 kg results in an increase in Cmax of 45.
There is a dose- proportionate increase in Cmax and AUC values following multiple doses ranging from 0.1-1 mg.
Following once daily dosing, steady state of plasma levels is obtained after 3 to 4 days with a 1.3-fold increase in Cmax and AUC.
There is a proportional increase in Cmax and AUC from 20 mg to 60 mg, the range of single-dose administrations tested.
Compared to subjects with normal hepatic function, patients with mild hepatic impairment had a mean increase in Cmax of 53% and in AUC of 26% of celecoxib.
A modest increase in Cmax(28%) was observed for zidovudine when administered with lamivudine,
Multiple once daily dosing of mirabegron IR resulted in a 90% increase in Cmax and a 229% increase in AUC of a single dose of metoprolol.
An increase in Cmax(26%) and AUC(29%)
considered a moderate CYP3A4 and a weak P-gp inhibitor, led to a 1.4-fold increase in mean apixaban AUC and a 1.3-fold increase in Cmax.
there was a statistically significant increase in erlotinib AUC and a borderline increase in Cmax when compared with values observed in another study in which erlotinib was given as single agent.
resulted in a 4-fold increase in vardenafil AUC and a 3-fold increase in Cmax.
a 1.4-fold increase in Cmax, ss, and a 2-fold increase in AUC(0-24)ss at 800 mg multiple doses in the severe renally impaired group(CLCR< 30 mL/ min) compared to healthy volunteers were observed and a reduced dosage of Ketek is recommended See Section 4.2.
mean rivaroxaban AUC and a 1.4 fold increase in Cmax.
a 1.4-fold increase in Cmax, ss, and a 2-fold increase in AUC(0-24)ss at 800 mg multiple doses in the severe renally impaired group(CLCR<
steady state is achieved on the first day of administration with no increase in Cmax or AUC after extended dosing.
of rosuvastatin and a 4.6-fold increase in Cmax.
In healthy subjects, co-administration of celecoxib 200 mg twice daily with 450 mg twice daily of lithium resulted in a mean increase in Cmax of 16% and in AUC of 18% of lithium.
An additional study evaluating the effects of a standardized medium-fat meal on the pharmacokinetics of bazedoxifene at steady-state showed a 42% and 35% increase in Cmax and AUC, respectively,
The combination of canagliflozin 300 mg once daily for 7 days with a single dose of digoxin 0.5 mg followed by 0.25 mg daily for 6 days resulted in a 20% increase in AUC and a 36% increase in Cmax of digoxin, probably due to inhibition of P-gp.
Dose related increases in Cmax and AUC were seen for doses up to 1,600 mg; the increases were less than proportional.
The increases in Cmax due to the change in formulation
The mean increase in olanzapine Cmax following fluvoxamine was 54% in female nonsmokers
there was a 5.3-fold increase in simvastatin Cmax, an 8.9-fold increase in simvastatin AUC, a 15-fold increase in simvastatin acid Cmax and an 11-fold increase in simvastatin acid AUC.
there was a 5.3 fold increase in simvastatin Cmax, an 8.9 fold increase in simvastatin AUC, a 15-fold increase in simvastatin acid Cmax and an 11-fold increase in simvastatine acid AUC.