Sta Znaci REVERSE TRANSCRIPTASE na Hrvatskom - Hrvatski Prijevod

• reverzne transkriptaze
• reverznu transkriptazu
• povratne transkriptaze
• reverzna transkriptaza
• reverznoj transkriptazi

Primjeri korištenja Reverse transcriptase na Engleski i njihovi prijevodi na Hrvatskom

Reverse transcriptase is an enzyme that HIV needs in order to multiply.
Reverzna transkriptaza je enzim potreban HIV-u radi umnožavanja.

Howard Temin and David Baltimore independently discovered reverse transcriptase enzymes.
Temin i Baltimore su istovremeno i neovisno jedan od drugoga otkrili enzima reverzna transkriptaza.

Reverse transcriptase is an enzyme that HIV needs in order to multiply.
Reverzna transkriptaza je enzim koji koji je HIV-u potreban da bi se umnažao.

Hbv and hiv antiviral agents: nucleos(t)ide reverse transcriptase inhibitors.
ANTIVIROTICI ZA LIJEČENJE INFEKCIJE HBV-om I HIV-om: NUKLEOZIDNI/NUKLEOTIDNI INHIBITORI REVERZNE TRANSKRIPTAZE.

By blocking reverse transcriptase, Genvoya reduces the amount of HIV-1 in the blood and keeps it at a low level.
Blokirajući reverznu transkriptazu Genvoya smanjuje količinu virusa HIV-1 u krvi i održava ga u malim koncentracijama.

The active substance in Ziagen, abacavir, is a nucleoside reverse transcriptase inhibitor NRTI.
Djelatna tvar lijeka Ziagen, abakavir, jest nenukleozidni inhibitor povratne transkriptaze NNRTI.

In addition, a K70E substitution in HIV-1 reverse transcriptase has been selected by tenofovir and results in low-level reduced susceptibility to abacavir, emtricitabine, lamivudine and tenofovir.
Uz to, tenofovirom je izdvojena K70E supstitucija u HIV-1 reverznoj transkriptazi što rezultira blagim smanjenjem osjetljivosti na abakavir, emtricitabin, lamivudin i tenofovir.

The active substance in Stocrin, efavirenz, is a non-nucleoside reverse transcriptase inhibitor NNRTI.
Djelatna tvar lijeka Stocrin, efavirenz, jest nenukleozidni inhibitor povratne transkriptaze NNRTI.

In addition, a K70E substitution in HIV-1 reverse transcriptase has been selected by tenofovir and results in low-level reduced susceptibility to abacavir, emtricitabine, tenofovir and lamivudine.
Osim toga, supstitucija K70E u HIV-1 reverznoj transkriptazi selektivno je izdvojena tenofovirom i dovela je do niske razine smanjene osjetljivosti na abakavir, emtricitabin, tenofovir i lamivudin.

The active substance in Intelence, etravirine, is a non-nucleoside reverse transcriptase inhibitor NNRTI.
Djelatna tvar lijeka Intelence, etravirin, je nenukleozidni inhibitor povratne transkriptaze NNRTI.

Tenofovir diphosphate inhibits HIV-1 reverse transcriptase and the HBV polymerase by direct binding competition with the natural deoxyribonucleotide substrate and, after incorporation into DNA, by DNA chain termination.
Tenofovir difosfat inhibira reverznu transkriptazu virusa HIV-1 i polimerazu virusa HBV izravno se natječući za vezno mjesto s prirodnim deoksiribonukleotidnim supstratom i, nakon ugradnje u DNK, završetkom DNK lanca.

Emtricitabine triphosphate and tenofovir diphosphate competitively inhibit HIV-1 reverse transcriptase, resulting in DNA chain termination.
Emtricitabin trifosfat i tenofovir difosfat kompetitivno inhibiraju reverznu transkriptazu virusa HIV-1, što rezultira prekidom lanca DNK.

Efavirenz non-competitively inhibits HIV-1 reverse transcriptase(RT) and does not significantly inhibit human immunodeficiency virus-2(HIV-2) RT or cellular deoxyribonucleic acid(DNA) polymerases α, β, γ, and δ.
Efavirenz je nekompetitivni inhibitor reverzne transkriptaze virusa HIV-1(RT) i nema svojstvo značajne inhibicije virusa humane imunodeficijencije 2(HIV-2) RT ili staničnih polimeraza(α, β, γ i δ) deoksiribonukleinske kiseline DNK.

The most common emergent resistance mutations in Eviplera-treated patients were M184V/I and E138K in reverse transcriptase.
Najčešće mutacije povezane s rezistencijom koja se pojavila na liječenje u pacijenata liječenih lijekom Eviplera bile su MV184V/I i E138K u reverznoj transkriptazi.

Emtricitabine triphosphate competitively inhibits HIV-1 reverse transcriptase(RT), resulting in deoxyribonucleic acid(DNA) chain termination.
Emtricitabin trifosfat kompetitivno inhibira HIV-1 reverznu transkriptazu(RT), što rezultira u prekidu lanca deoksiribonukleinske kiseline(DNK).

Similarly the potential for cross-resistance between nevirapine and NRTIs is low because the molecules have different binding sites on the reverse transcriptase.
Također, potencijal ukrižene reaktivnosti nevirapina i NRTI je nizak budući da se ti lijekovi vežu na različita mjesta na reverznoj transkriptazi.

Each of these active substances works by interfering with an enzyme called‘reverse transcriptase', which is essential for the HIV-1 virus to multiply.
Svaka od ovih djelatnih tvari djeluje tako što utječe na enzim koji se naziva„reverzna transkriptaza“, koji je nužan za umnažanje virusa HIV-1.

Plants that have reverse transcriptase blockers are effective against HIV but are completely ineffective against DNA or RNA viruses that do not need reverse transcriptase because they replicate their nucleus using other types of DNA or RNA polymerases.
Biljke koje u sebi imaju obrnuti blokatori transkriptaze su učinkoviti protiv HIV-a, ali potpuno neučinkovit protiv DNA i RNA virusa, koji ne zahtijevaju reverzne transkriptaze, jer je njegova jezgra replicirati druge vrste DNA ili RNA polimeraza.

Resistance is mediated by reduced inhibitor binding to the altered HBV reverse transcriptase, and resistant HBV exhibits reduced replication capacity in cell culture.
Rezistencija je posredovana smanjenim vezanjem inhibitora za promijenjenu HBV reverznu transkriptazu, a rezistentni HBV pokazuje smanjeni kapacitet umnažanja u staničnoj kulturi.

In the second study, Edurant was compared with efavirenz, when both medicines were given in combination with a fixed regimen of antiviral medicines consisting of tenofovir disoproxil and emtricitabine or two other nucleoside or nucleotide reverse transcriptase inhibitors.
U drugom ispitivanju Edurant je uspoređen s efavirenzom, pri čemu su oba lijeka uzimana u kombinaciji s fiksnim režimom protuvirusnih lijekova koji se sastoji od tenofovirdizoproksila i emtricitabina ili dva druga nukleozidna ili nukleotidna inhibitora reverzne transkriptaze.

Viruses can also contain enzymes for infecting cells, such as the HIV integrase and reverse transcriptase, or for viral release from cells, like the influenza virus neuraminidase.[76].
Virusi također mogu sadržavati enzime za inficiranje ćelija, kao što su aHIV integraze i reverzna transkriptaza ili za oslobađanje ćelija od virusa, kao što je virus gripa- neuraminidaza.

Medicines used to treat hypertension and heart problems(such as diltiazem, nifedipine, nitrendipine, verapamil, felodipine, amlodipine); some medicines used to treat HIV(antiretroviral medicines): protease inhibitors(such as amprenavir, atazanavir, indinavir, nelfinavir, ritonavir), non-nucleoside reverse transcriptase inhibitors(such as efavirenz, nevirapine);
Lijekovi za liječenje hipertenzije i srčanih tegoba( kao što su diltiazem, nifedipin, nitrendipin, verapamil, felodipin, amlodipin); neki lijekovi za liječenje HIV-a( antiretrovirusni lijekovi): inhibitori proteaze( kao što su amprenavir, atazanavir, indinavir, nelfinavir, ritonavir), nenukleozidni inhibitori reverzne transkriptaze( kao što su efavirenz, nevirapin);

In vitro studies have demonstrated that its mechanism of action in relation to HIV is inhibition of the HIV reverse transcriptase enzyme, an event which results in chain termination and interruption of the viral replication cycle.
Studije in vitro pokazuju da je njegov mehanizam djelovanja prema HIV-u inhibicija enzima reverzne transkriptaze HIV-a, koja dovodi do terminacije lanca i prekida replikacije virusnog ciklusa.

Emtricitabine is phosphorylated by cellular enzymes to form emtricitabine 5'-triphosphate, which competitively inhibits HIV-1 reverse transcriptase, resulting in DNA chain termination.
Stanični enzimi fosforiliraju emtricitabin u emtricitabin5'-trifosfat koji kompetitivno inhibira HIV-1 reverznu transkriptazu, što rezultira prekidom lanca DNK.

Nevirapine is a non-competitive inhibitor of the HIV-1 reverse transcriptase, but it does not have a biologically significant inhibitory effect on the HIV-2 reverse transcriptase or on eukaryotic DNA polymerases α, β, γ, or δ.
Nevirapin je nekompetitivan inhibitor HIV-1 reverzne transkriptaze, ali nema biološki značajan inhibitorni učinak na HIV-2 reverznu transkriptazu ili na eukariotske DNK- polimeraze , , , ili .

Each of these active substances, also known as antiretroviral medicines, work by interfering with an enzyme(reverse transcriptase) that is essential for the virus to multiply.
Te su djelatne tvari poznate i kao antiretrovirusni lijekovi, a svaka od njih djeluje na način da inhibira enzim(reverznu transkriptazu) koji je nužan za umnožavanje virusa.

When co-administering CYP3A4 inducers(i.e., aminoglutethimide, nafcillin, non-nucleoside reverse transcriptase inhibitors, phenobarbital, rifampicin, carbamazepine, pioglitazone, St John's Wort, glucocorticoids, modafinil and phenytoin) with Lojuxta, the possibility of a drug-drug interaction affecting efficacy should be considered.
Kad se Lojuxta primjenjuje istodobno s induktorima CYP3A4(tj. aminoglutetimidom, nafcilinom, nenukleozidnim inhibitorima reverzne transkriptaze, fenobarbitalom, rifampicinom, karbamazepinom, pioglitazonom, gospinom travom, glukokortikoidima, modafinilom i fenitoinom), potrebno je uzeti u obzir mogućnost interakcije lijekova koja utječe na djelotvornost.

Each of these active substances, also known as antiretroviral medicines, works by interfering with an enzyme(a protein called‘reverse transcriptase') that is essential for the virus to multiply.
Svaka od ovih djelatnih tvari, koje se još zovu antiretrovirusni lijekovi, djeluje tako da ometa enzim(bjelančevinu koja se zove„reverzna transkriptaza”) neophodan za umnažanje virusa.

The antiviral activity of abacavir in cell culture was not antagonized when combined with the nucleoside reverse transcriptase inhibitors(NRTIs) didanosine, emtricitabine, lamivudine, stavudine, tenofovir or zidovudine, the non-nucleoside reverse transcriptase inhibitor(NNRTI) nevirapine, or the protease inhibitor(PI) amprenavir.
Antivirusna aktivnost abakavira u kulturi stanica nije bila antagonizirana kad se primjenjivao u kombinaciji s nukleozidnim inhibitorima reverzne transkriptaze(NRTI) didanozinom, emtricitabinom, lamivudinom, stavudinom, tenofovirom ili zidovudinom, s nenukleozidnim inhibitorom reverzne transkriptaze(NNRTI) nevirapinom ili inhibitorom proteaze(PI) amprenavirom.

Resistance to emtricitabine or tenofovir has been seen in vitro and in the HIV-1 from some patients due to the development of the M184V or M184I emtricitabine resistance substitution in reverse transcriptase or the K65R tenofovir resistance substitution in reverse transcriptase.
Rezistencija na emtricitabin i tenofovir bila je opažena in vitro i u nekih pacijenata inficiranih virusom HIV-1, zbog razvoja M184V ili M184I supstitucije rezistencije na emtricitabin u reverznoj transkriptazi ili K65R supstitucije rezistencije na tenofovir u reverznoj transkriptazi.