What is the translation of " IS NOT A SUBSTRATE " in Croatian?

• nije supstrat

Examples of using Is not a substrate in English and their translations into Croatian

Idebenone is not a substrate for p-gp in vitro.
Idebenon nije substrat za g-gp in vitro.

When incubated with pooled human liver microsomes, tedizolid was stable suggesting that tedizolid is not a substrate for hepatic CYP450 enzymes.
Kada je inkubiran sa sakupljenim mikrosomima ljudske jetre, tedizolid je bio stabilan, što ukazuje na to da tedizolid nije supstrat za jetrene enzime CYP450.

Pitolisant is not a substrate of OATP1B1, OATP1B3.
Pitolizant nije supstrat prijenosnika OATP1B1, OATP1B3.

Pasireotide is metabolically highly stable and in vitro data show that pasireotide is not a substrate, inhibitor or inducer of any major enzymes of CYP450.
Pasireotid je metabolički visoko stabilan, a in vitro podaci pokazuju da pasireotid nije supstrat, inhibitor ili induktor bilo kojeg od glavnih enzima CYP450.

Enzalutamide is not a substrate of the efflux transporters P-gp or BCRP.
Enzalutamid nije supstrat efluksnih prijenosnika P-gp ili BCRP.

In-vitro studies indicate that ertapenem does not inhibit P-glycoprotein-mediated transport of digoxin or vinblastine and that ertapenem is not a substrate for P-glycoprotein-mediated transport.
Istraživanja in vitro ukazuju da ertapenem ne inhibira transport digoksina i vinblastina posredovan P-glikoproteinom, kao i da ertapenem nije supstrat za transport posredovan P-glikoproteinom.

Caspofungin is not a substrate for P-glycoprotein and is a poor substrate for cytochrome P450 enzymes.
Kaspofungin nije supstrat P-glikoproteina i slab je supstrat enzima citokroma P450.

Dose reduction of the glucocorticoid should be considered with close monitoring of local and systemic effects or a switch to a glucocorticoid, which is not a substrate for CYP3A4 e.g. beclomethasone.
Treba razmisliti o smanjenju doze glukokortikoida uz pomno praćenje lokalnih i sustavnih učinaka, ili prijelazu na neki glukokortikoid koji nije supstrat CYP3A4 npr. beklometazon.

Caspofungin is not a substrate for P-glycoprotein enzymes and represents a poor substrate for cytochrome P450 enzymes.
Kaspofungin nije supstrat enzima i P-glikoprotein i predstavlja slaba podloga za citokroma P450.

Preliminary in vitro studies have shown that safinamide is not a substrate for the transporters P-gp, BCRP, OAT1B1, OAT1B3, OATP1A2 or OAT2P1.
Preliminarna in vitro ispitivanja pokazala su da safinamid nije supstrat za transportere P-gp, BCRP, OAT1B1, OAT1B3, OATP1A2 ili OAT2P1.

Migalastat is not a substrate for MDR1 or BCRP, nor is it an inhibitor of BCRP, MDR1, or BSEP human efflux transporters.
Migalastat nije supstrat za MDR1 ili BCRP, niti je inhibitor humanih efluksnih transportera BCRP, MDR1 ili BSEP.

Eluxadoline has a low potential for drug-drug interactions based on limited in vitro CYP inhibition/induction and given that eluxadoline is not a substrate for CYPs at clinically meaningful concentrations.
Eluksadolin ima niski potencijal za interakciju s drugim lijekovima na temelju ograničene in vitro CYP inhibicije/indukcije i s obzirom da eluksadolin nije supstrat za CYP-ove pri klinički značajnim koncentracijama.

In vitro data also show that olaparib is not a substrate for OATP1B1, OATP1B3, OCT1, BCRP or MRP2 and not an inhibitor of OATP1B3, OAT1 or MRP2.
In vitro podaci pokazuju i da olaparib nije supstrat za OATP1B1, OATP1B3, OCT1, BCRP ili MRP2 niti inhibitor OATP1B3, OAT1 ili MRP2.

A dose reduction of the glucocorticoid should be considered with close monitoring of local and systemic effects or a switch to a glucocorticoid, which is not a substrate for CYP3A4 e.g., beclomethasone.
Potrebno je razmotriti sniženje doze glukokortikoida uz pažljivo praćenje lokalnih i sistemskih učinaka ili prebacivanje na glukokortikoid koji nije supstrat enzima CYP3A4 npr., beklometazon.

Based on in vitro studies lurasidone is not a substrate of CYP1A1, CYP1A2, CYP2A6, CYP4A11, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6 or CYP2E1 enzymes.
Zasnovano na ispitivanjima in vitro, lurasidon nije supstrat CYP1A1, CYP1A2, CYP2A6, CYP4A11, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6 ili CYP2E1 enzima.

A dose reduction of the glucocorticoid should be considered with close monitoring of local and systemic effects or a switch to a glucocorticoid which is not a substrate for CYP3A e.g., beclomethasone.
Mora se razmotriti smanjenje doze glukokortikosteroida uz pomno praćenje lokalnih i sistemskih učinaka ili prebacivanje na liječenje s glukokortikosteroidima koji nisu supstrati za CYP3A npr. beklometazon.

In vitro data indicate that enzalutamide is not a substrate for OATP1B1, OATP1B3, or OCT1; and N-desmethyl enzalutamide is not a substrate for P-gp or BCRP.
In vitro podaci pokazuju da enzalutamid nije supstrat za OATP1B1, OATP1B3 ili OCT1; i N-desmetil enzalutamid nije supstrat za P-gp ili BCRP.

In vitro studies indicated that eluxadoline is a substrate and an inhibitor of the hepatic uptake transporter OATP1B1; a substrate for the hepatic efflux transporter MRP2 and is not a substrate or inhibitor of the P-gp and BCRP transporters.
In vitro ispitivanja pokazala su da je eluksadolin supstrat i inhibitor prijenosnika jetrenog unosa OATP1B1; supstrat prijenosnika jetrenog efluksa MRP2 i da nije supstrat niti inhibitor prijenosnika P-gp-a i BCRP-a.

Sofosbuvir is not a substrate for hepatic uptake transporters, organic anion-transporting polypeptide(OATP) 1B1 or 1B3, and organic cation transporter(OCT) 1.
Sofosbuvir nije supstrat jetrenih prijenosnika za unos tvari, polipeptida za prijenos organskih aniona(OATP) 1B1 ili 1B3 i prijenosnika organskih kationa(OCT) 1.

Based on in vitro studies utilising human liver enzymes, lurasidone is not a substrate for CYP1A2; smoking should, therefore, not have an effect on the pharmacokinetics of lurasidone.
Zasnovano na in vitro ispitivanjima korištenjem ljudskih jetrenih enzima, lurasidon nije supstrat za CYP1A2; stoga pušenje ne bi trebalo utjecati na farmakokinetiku lurasidona.

Obinutuzumab is not a substrate, inhibitor, or inducer of cytochrome P450(CYP450), uridine diphosphate glucuronyltransferase(UGT) enzymes and transporters such as P-glycoprotein.
Obinutuzumb nije supstrat, inhibitor niti induktor citokroma P450(CYP450), enzima uridin difosfat glukuronoziltransferaze(UGT) niti prijenosnika poput P-glikoproteina.

While subject to active tubular secretion, GS-331007 is not a substrate for renal transporters including organic anion transporter(OAT) 1 or 3, OCT2, MRP2, P-gp, BCRP or MATE1.
Iako je podložan aktivnoj tubularnoj sekreciji, GS-331007 nije supstrat bubrežnih prijenosnika uključujući prijenosnik organskih aniona(OAT) 1 ili 3, OCT 2, MRP2, P-gp, BCRP ili MATE1.

Migalastat is not a substrate for P-glycoprotein(P-gP) in vitro and it is considered unlikely that migalastat would be subject to drug-drug interactions with cytochrome P450s.
Migalastat nije supstrat za P-glikoprotein(P-gP) in vitro i ne smatra se vjerojatnim da bi migalastat bio podložan interakciji lijekova s citokromima P450.

In vitro studies indicate that raltegravir is not a substrate of cytochrome P450(CYP) enzymes, does not inhibit CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6 or CYP3A, does not induce CYP3A4 and does not inhibit P-glycoprotein-mediated transport.
Istraživanja in vitro pokazuju da raltegravir nije supstrat enzima citokroma P450(CYP), ne inhibira CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6 ili CYP3A, ne inducira CYP3A4 niti inhibira transport posredovan P-glikoproteinom.

Degarelix is not a substrate for the human CYP450 system and has not been shown to induce or inhibit CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, or CYP3A4/5 to any great extent in vitro.
Degareliks nije supstrat sustava CYP450 u ljudi i nije se pokazalo da in vitro u većoj mjeri inducira ili inhibira CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1 ili CYP3A4/5.

In addition, migalastat is not a substrate for MATE1, MATE2-K, OAT1, OAT3, or OCT2, nor is it an inhibitor of OATP1B1, OATP1B3, OAT1, OAT3, OCT1, OCT2, MATE1, or MATE2-K human uptake transporters.
Osim toga, migalastat nije supstrat za MATE1, MATE2-K, OAT1, OAT3 ili OCT2 niti je inhibitor humanih transportera za unos OATP1B1, OATP1B3, OAT1, OAT3, OCT1, OCT2, MATE1 ili MATE2-K.

Because Xiapex is not a substrate for cytochrome P450 or other medicinal product metabolizing enzyme pathways, and because no active metabolites are expected, no metabolism studies have been performed.
Budući da Xiapex nije supstrat citokroma P450 niti nekog drugog enzimskog puta kojim se metaboliziraju lijekovi i budući da se ne očekuju nikakvi aktivni metaboliti, nisu provedena ispitivanja metabolizma.

In vitro, brivaracetam is not a substrate of human P- glycoprotein(P-gp), multidrug resistance proteins(MRP) 1 and 2, and likely not organic anion transporter polypeptide 1B1(OATP1B1) and OATP1B3.
In vitro, brivaracetam nije supstrat ljudskog P-glikoproteina(P-gp) ni proteina rezistencije na više lijekova(engl. multidrug resistance proteins, MRP) 1 i 2, te vjerojatno ni prijenosnog polipeptida organskih aniona 1B1(OATP1B1) i OATP1B3.

Eribulin is not a substrate of breast cancer resistance protein(BCRP), organic anion(OAT1, OAT3, OATP1B1, OATP1B3), multi-drug resistance-associated protein(MRP2, MRP4) and bile salt export pump(BSEP) transporters.
Eribulin nije supstrat sljedećih prijenosnih proteina: proteina rezistencije raka dojke(BCRP), transportera organskih aniona(OAT1, OAT3, OATP1B1, OATP1B3), proteina multirezistencije na lijekove(MRP2, MRP4) i pumpe za izbacivanje žučnih soli BSEP.

Based on in vitro data pasireotide is not a substrate of the efflux transporter BCRP(breast cancer resistance protein) nor of the influx transporters OCT1(organic cation transporter 1), OATP(organic anion-transporting polypeptide) 1B1, 1B3 or 2B1.
Na temelju in vitro podataka pasireotid nije supstrat BCRP transportera za izbacivanje(engl. breast cancer resistance protein- protein rezistencije raka dojke) niti transportera za ubacivanje OCT1(engl. organic cation transporter 1- transporter organskih kationa 1), OATP(engl. organic anion-transporting polypeptide- polipeptid koji transportira organske anione) 1B1, 1B3 ili 2B1.