Examples of using Is not a substrate in English and their translations into Polish
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Medicine
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Colloquial
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Official
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Ecclesiastic
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Ecclesiastic
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Official/political
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Computer
Fenofibrate is not a substrate for CYP 3A4.
In vitro studies have also indicated that eribulin is not a substrate for OCT1.
Macitentan is not a substrate for P- gp/MDR-1.
Rimonabant displays high in vitro permeability and is not a substrate of P-glycoprotein.
Fampridine is not a substrate for P-glycoprotein.
When incubated with pooled human liver microsomes,tedizolid was stable suggesting that tedizolid is not a substrate for hepatic CYP450 enzymes.
Idebenone is not a substrate for p-gp in vitro.
Pasireotide is metabolically highly stable andin vitro data show that pasireotide is not a substrate, inhibitor or inducer of CYP450.
Ulipristal acetate is not a substrate for either OATP1B1 or OATP1B3.
In-vitro studies indicate that ertapenem does not inhibit P-glycoprotein-mediated transport of digoxin or vinblastine and that ertapenem is not a substrate for P-glycoprotein-mediated transport.
Sitagliptin is not a substrate for OCT2 or OAT1 or PEPT1/ 2 transporters.
In vitro studies have shown that degarelix is not a substrate for the human CYP450 system.
Enzalutamide is not a substrate of the efflux transporters P-gp or BCRP.
Pasireotide is metabolically highly stable andin vitro data show that pasireotide is not a substrate, inhibitor or inducer of any major enzymes of CYP450.
Entecavir is not a substrate, inducer or an inhibitor of cytochrome P450(CYP450) enzymes.
Eltrombopag is a substrate for BCRP, but is not a substrate for P-glycoprotein or OATP1B1.
Telbivudine is not a substrate, inhibitor or inducer of the cytochrome P450(CYP450) enzyme system.
Biotransformation: entecavir is not a substrate, inhibitor or inducer of the CYP450 enzyme system.
Vandetanib is not a substrate of multidrug resistance protein 2(MRP2), p-glycoprotein(P-gp) or breast cancer resistance protein BCRP.
In vitro studies demonstrated that eltrombopag is not a substrate for the organic anion transporter polypeptide, OATP1B1, but is an inhibitor of this transporter.
Entecavir is not a substrate, an inducer or an inhibitor of cytochrome P450(CYP450) enzymes see section 5.2.
Based on in vitro studies utilising human liver enzymes,lurasidone is not a substrate for CYP1A2; smoking should, therefore, not have an effect on the pharmacokinetics of lurasidone.
Ponatinib is not a substrate for the human organic anion transporting polypeptides OATP1B1, OATP1B3 and the organic cation transporter OCT-1.
OXO, despite its structural similarity to testosterone, is not a substrate for aromatase, so it does not aromatize to estrogens and does not show any activity attributed to estrogens.
Fluoxetine is not a substrate of Pgp, and thus a switch from paroxetine or citalopram to fluoxetine may be beneficial to the nonresponders.
Based on in vitro studies lurasidone is not a substrate of CYP1A1, CYP1A2, CYP2A6, CYP4A11, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6 or CYP2E1 enzymes.
Caspofungin is not a substrate for P-glycoprotein and is a poor substrate for cytochrome P450 enzymes.
Since corifollitropin alfa is not a substrate of cytochrome P450 enzymes, no metabolic interactions with other medicinal products are anticipated.
Sofosbuvir is not a substrate for hepatic uptake transporters, organic anion-transporting polypeptide(OATP) 1B1 or 1B3, and organic cation transporter(OCT) 1.