Examples of using Multiple doses in English and their translations into Croatian
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Each pen contains multiple doses.
Jedna brizgalica sadrži više doza lijeka.Single and multiple doses of 8 mg and 12 mg impaired psychomotor performance in healthy volunteers in a dose-related manner.
Jednokratne i višekratne doze od 8 mg i 12 mg narušile su psihomotornu sposobnost zdravih dobrovoljaca ovisno o Ingle dose/cobicistat 150 mg multiple doses.
Multiple doses of ambrisentan had no effect on cyclosporine A exposure, and no dose adjustment of cyclosporine A is warranted.
Višekratne doze ambrisentana nemaju učinak na izloženost ciklosporinu A te nema potrebe za prilagodbom Single dose versus multiple doses.
Jednokratna doza u odnosu na višekratno doziranje.There is little or no accumulation of topotecan with repeated daily dosing andthere is no evidence of a change in the PK after multiple doses.
Pri ponovljenom svakodnevnom doziranju topotekan se malo ili uopće ne kumulira tenema dokaza o promjeni PK nakon višestrukih doza.Accumulation of parent drug or monomethyl fumarate does not occur with multiple doses of dimethyl fumarate at the therapeutic regimen.
U terapijskom režimu s višestrukim dozama dimetilfumarata ne dolazi do nakupljanja izvornog lijeka ili monometilfumarata.There is little or no accumulation of topotecan with repeated daily dosing andthere is no evidence of a change in the PK after multiple doses.
Topotekan se akumulira u manjoj količini ili se uopće ne akumulira nakon ponovljenih dnevnih There was a small benefit in the relief of nasal congestion from multiple doses, but it was unclear if this was beneficial for patients.
Našli smo malu prednost u ublažavanju začepljenosti nosa(nazalne kongestije) s višestrukim dozama, no nije bilo jasno je li to korisno za bolesnike.Co-administration of multiple doses of empagliflozin and metformin does not meaningfully alter the pharmacokinetics of either empagliflozin or metformin in healthy subjects.
Istodobna primjena višekratnih doza empagliflozina i metformina ne mijenja značajno farmakokinetiku, niti empagliflozina ni metformina u zdravih ispitanika.Lesinurad does not accumulate following multiple doses.
Lesinurad se ne akumulira nakon primjene višestrukih doza.Co-administration of pitolisant with rifampicin in multiple doses significantly decreases pitolisant mean Cmax and AUC ratio about 39% and 50%.
Istodobna primjena pitolizanta s rifampicinom u višestrukim dozama značajno smanjuje omjer srednje vrijednosti Cmax i AUC-a pitolizanta za približno 39% i 50.Digoxin(0.5 mg single dose)/Cobicistat 150 mg multiple doses.
The steady-state mean Cmax, AUCtau, and Ctrough(mean± SD) following multiple doses of Stribild in HIV-1 infected subjects, respectively, were 1.7± 0.39 µg/mL.
Srednje vrijednosti Cmax, AUCtau i Ctrough(srednje ± SD) u stanju dinamičke ravnoteže nakon više doza Stribilda u pacijenata zaraženih virusom HIV-1 bile su.In accordance with the half-life, the accumulation index is 5 to 6 based on AUC0-24h following multiple doses of 5 to 20 mg/day.
Sukladno poluvremenu, indeks nakupljanja je 5 do 6 na temelju AUC0-24h nakon višekratnih doza od 5 do 20 mg/dan.Multiple doses of mirabegron up to 300 mg daily for 10 days showed increases in pulse rate and systolic blood pressure when administered to healthy volunteers.
Višekratne doze mirabegrona do 300 mg na dan kroz 10 dana izazvale su ubrzanje pulsa i porast sistoličkog krvnog tlaka, kada je lijek primjenjivan na zdravim dobrovoljcima.The maximum amount of Aranesp that can be safely administered in single or multiple doses has not been determined.
Maksimalna količina Aranespa koja se može sigurno primijeniti u pojedinačnoj ili višestrukim dozama nije određena.However, multiple doses of ambrisentan had no clinically relevant effect on cyclosporine A exposure, and no dose adjustment of cyclosporine A is warranted.
Međutim, višekratne doze ambrisentana nisu imale relevantan klinički značaj na izloženost ciklosporinu A, te nije sigurna potreba prilagodbe Canagliflozin does not exhibit time-dependent pharmacokinetics, andaccumulated in plasma up to 36% following multiple doses of 100 mg and 300 mg.
Kanagliflozin ne pokazuje farmakokinetiku ovisnu o vremenu, tese akumulirao u plazmi do 36% nakon višekratnih doza od 100 mg i 300 mg.The mean total body systemic clearance of pegvisomant following multiple doses is estimated to be 28 ml/h for subcutaneous doses ranging from 10 to 20 mg/day.
Prosječni ukupni tjelesni sistemski klirens pegvisomanta nakon višekratnih doza procijenjen je na 28 ml/h kod supkutane primjene There is little or no accumulation of topotecan with repeated daily dosing andthere is no evidence of a change in the PK after multiple doses.
Postoji zanemarivo nakupljanje ili nema nakupljanja topotekana nakon primjene ponovljenih dnevih Irrespective of the dose and whether lixisenatide was administered as single or multiple doses, the median tmax is 1 to 3.5 hours in patients with type 2 diabetes.
Neovisno o dozi i o tome primjenjuje li se liksisenatid u obliku jedne ili više doza, medijantmax u bolesnika sa šećernom bolešću tipa 2 iznosi 1-3, 5 sati.Plasma levels of Canrenone powder and‘total metabolites' after base hydrolysis were compared in young andelderly subjects following single and multiple doses of spironolactone.
Razine plazme praha kanrenona i"ukupni metaboliti" nakon bazične hidrolize uspoređeni su u mladih istarijih osoba nakon jednokratnih i višestrukih doza spironolaktona.In clinical trials of other quinolones using multiple doses patients were marked ophthalmic disorders, including cataracts, Multiple point clouding of the lens.
U kliničkim ispitivanjima drugih kinolona koristeći višestruke doze pacijenata su označene oftalmičkih poremećaja, uključujući katarakte, Višestruki točka zamućenje leće.The mean terminal elimination half-life of stavudine is 1.3 to 2.3 hours following single or multiple doses, and is independent of dose. .
Prosječno terminalno poluvrijeme eliminacije stavudina je 1, 3 do 2, 3 sata nakon jedne ili više doza i ne ovisi o veličini Co- administration of multiple doses of linagliptin and metformin did not meaningfully alter the pharmacokinetics of either linagliptin or metformin in healthy volunteers and patients.
Istovremena primjena višekratnih doza linagliptina i metformina nije značajno promijenila farmakokinetiku bilo linagliptina ili metformina u zdravih dobrovoljaca i bolesnika.The overall exposure of adolescents(12 to≤17 years) and children(2 to< 12 years)to deferasirox after single and multiple doses was lower than that in adult patients.
Ukupna izloženost deferasiroksu adolescenata(12 do ≤17 godina) i djece(2 do< 12 godina)nakon jednokratne i višestrukih doza bila je niža od one u odraslih bolesnika.Multiple doses of 90 mg per day for 12 days in a patient resulted in pneumonia, systemic inflammatory response, atrial fibrillation, and asymptomatic, moderate pericardial effusion.
Višestruke doze od 90 mg dnevno tijekom 12 dana rezultirale su pneumonijom, sistemnim upalnim odgovorom organizma, fibrilacijom atrija i asimptomatskom, umjerenom efuzijom perikarda.No clinically relevant effect was observed during steady-state lithium exposure following co- administration with multiple doses of vortioxetine in healthy subjects.
Nije opažen klinički relevantan učinak tijekom izloženosti litiju u stanju dinamičke ravnoteže nakon istodobne primjene s višekratnim dozama vortioksetina u zdravih ispitanika.It was demonstrated in a clinical study with intravenous midazolam that multiple doses of telavancin had no effect on the pharmacokinetics of midazolam, which is a sensitive substrate for CYP3A4.
Kliničkim je ispitivanjima s intravenskim uzimanjem midazolama pokazano da višekratne doze telavancina ne utječu na farmakokinetiku midazolama koji je osjetljivi supstrat za CYP3A4.
