Examples of using Multiple doses in English and their translations into Vietnamese
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The mean observed accumulation ratio of reslizumab following multiple doses of administration ranged from 1.5 to 1.9-fold.
There is little or no accumulation of topotecan with repeated daily dosing andthere is no evidence of a change in pharmacokinetics after multiple doses.
Whether you are taking one drug dose or multiple doses each day, it can be challenging to remember to take the right pill at the right time.
Most studies have shown that the best results were given aftertaking doses of 500-1000 mcg split into multiple doses throughout the day.
The CDC recommends multiple doses of the tetanus vaccine(that also protects against other infections such as whooping cough) for children: one dose at 2, 4 and 6 months each;
Because they don't use the whole virus or bacteria,side effects aren't as common as with live or inactivated vaccines, but multiple doses are often needed to be effective.
This effect can be particularly worrisome when multiple doses accumulate over the course of a treatment[6] or when the kidney concentrates urine by increasing tubular reabsorption during sleep.
Comparative BA or bioequivalence(BE) studies may use Pharmacokinetic(PK), Pharmacodynamic(PD), clinical or in vitro dissolution endpoints,and may be either single dose or multiple doses.
Multiple doses of dapoxetine(60 mg/day for 6 days) followed by a single 50 mg dose of desipramine increased the mean Cmax and AUCinf of desipramine by approximately 11% and 19%, respectively, compared to desipramine administered alone.
In a study in which multiple, subcutaneous doses of both 25 and 50 µg/kg were administered to cancer patients receiving chemotherapy, Neumega did not accumulate and clearance of Neumega was not altered following multiple doses.
Even if a single-dose or single-use vial appears to contain multiple doses or contains more medication than is needed for a single patient, that vial should not be used for more than one patient nor stored for future use on the same patient.
An effective dose of Carnitine- Pay attention to the supplements directions as well, because some may have less than the effective dose per serving,but direct you to take multiple doses a day which equate to the effective carnitine dosage range.
After an incident in 1951,where a US Navy officer attempted suicide with multiple doses of warfarin in rodenticide but recovered fully after presenting to a hospital and being treated with vitamin K(by then known as a specific antidote), studies began in the use of warfarin as a therapeutic anticoagulant.
A retrospective population pharmacokinetic analysis was conducted in 324 subjects(181 children 1 to 5 years of age, 18 children 6 to 11 years of age, and 124 adults 18 to 55 years of age)who received single or multiple doses of levocetirizine ranging from 1.25 mg to 30 mg.
Rodents are disinclined to gorge on an unknown food(perhaps reflecting an adaptation to their inability to vomit), preferring to sample, wait and observe whether it makes them or other rats sick.[1][2] This phenomenon of poison shynessis the rationale for poisons that kill only after multiple doses.
There were four multiple dose trials included in the new drug application.
Multiple dosing of dapoxetine(60 mg/day for 6 days) did not inhibit the metabolism of a single 40 mg dose of omeprazole.
Multiple dose pharmacokinetics were studied in a small number of children aged 3- 12 enrolled in a clinical trial.
Multiple dosing of dapoxetine(60 mg/day for 6 days) did not affect the pharmacokinetics or pharmacodynamics of a single 5 mg dose of glyburide.
Anavar has a half-life of only 10 hours, and it's estimated it's only actually effective for 5 hours,so multiple dosing is recommended.
In addition to pioglitazone, M-III and M-IV are the principal drug-relatedspecies found in human serum following multiple dosing.
Hydrochlorothiazide: In a pharmacokinetic interaction study, coadministration of multiple dose hydrochlorothiazide to healthy volunteers receiving fluconazole increased plasma concentrations of fluconazole by 40%.
Concentrations in kidney andlung were 10 to 13 times those of plasma concentrations after multiple dose therapy and 25 to 70% of the plasma level was found in the brain, spinal cord and cerebrospinal fluid.
Multiple dosing of dapoxetine(60 mg/day for 6 days) decreased the AUCinf of midazolam(8 mg single dose) by approximately 20%(range- 60 to +18%).
Multiple dosing of dapoxetine(60 mg/day for 6 days) decreased the AUCinf of midazolam(8 mg single dose) by approximately 20%(range- 60 to +18%).
That being said, a phase 1B randomized multiple dose escalation study reported that administration of 40 mg doses of NSI-189 once/day, 40 mg twice/day, and 40 mg three/day for 28 days.
Unused medications(including multiple dose vials containing diluents) or supplies(syringes, alcohol swabs, etc.) taken to a patient's station should be used only for that patient and should not be returned to a common clean area or used on other patients.
When multiple dose medication vials are used(including vials containing diluents), individual patient doses should be prepared in a clean(centralized) area away from dialysis stations and delivered separately to each patient.