Examples of using Accelerated phase in English and their translations into German
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Accelerated phase.
Can be used in different phases of the disease chronic, accelerated phase and blast crisis.
Accelerated Phase CML.
The recommended dosage of Imatinib Tevais 600 mg/day for adult patients in accelerated phase.
Accelerated phase CML and blast crisis and Ph+ ALL.
CML in the chronic phase after failure of interferon-alpha therapy, or in the accelerated phase.
Paediatric accelerated phase CML and blast.
Bosulif is used totreat three stages of CML called‘chronic phase',‘accelerated phase' and‘blast phase. .
Accelerated phase CML and blast crisis and Ph.
Clinical study in imatinib-resistant or intolerant CML in chronic phase, accelerated phase, and blast phase. .
Had received prior chemotherapy for treatment of either accelerated phase or blast crisis(“ pretreated patients”) whereas 165(63%) had not“ untreated patients”.
Adult and paediatric patients with Ph+ CML inchronic phase after failure of interferon-alpha therapy, or in accelerated phase or blast crisis.
The frequency of these events is greater in patients with accelerated phase CML(AP-CML) or blast phase CML(BP-CML)/Ph+ ALL than in chronic phase CML CP-CML.
In children and adolescents, Imatinib Actavis can beused in different phases of the disease chronic, accelerated phase and blast crisis.
Accelerated phase is an intermediate phase among the chronic phase and the onset of the blast crisis; it is considered as the first manifestation of resistance to therapy.
Stem cell transplant for all blastic phase patients, and for accelerated phase patients who do not achieve optimal response.
Accelerated phase is an intermediate phase among the chronic phase and the onset of blast crisis; it is considered as the first manifestation of resistance to therapy.
Major cytogenetic response, haematological response, molecular response(evaluation of minimal residual disease),time to accelerated phase or blast crisis and survival are main secondary endpoints.
Tasigna is indicated for the treatment of adults with chronic phase and accelerated phase Philadelphia chromosome positive chronic myelogenous leukaemia(CML) with resistance or intolerance to prior therapy including imatinib.
However, the occurrence of these cytopenias is likely to be related to the stage of thedisease being treated and they were more frequent in patients with accelerated phase CML or blast crisis as compared to patients with.
Treatment was discontinued for adverse reactions in 11% of patients in chronic phase CML,12% in accelerated phase CML, 15% in myeloid blast phase CML, and 8% in lymphoid blast phase CML or Ph+ ALL.
It is also used in children in the‘chronic phase' of the disease if it is not responding to interferon alpha(another medicine used to treat cancer),and in more advanced phases of the disease‘accelerated phase' and‘blast crisis.
In the 1980s it had to be assumedthat the"changes man causes in the natural environment[have] turn[ed] into an accelerated phase of destruction of soil, water, air, flora and fauna, affecting all fundamental conditions of human life.
It is also used in adults and children in the‘chronic phase' of the disease if it is not responding to interferon alpha(another cancer medicine),and in more advanced phases of the disease(‘accelerated phase' and‘blast crisis');
Grade 3 or 4 elevations of transaminases or bilirubin were reported in<5% of patients with chronic or accelerated phase CML but elevations were reported with an increased frequency of 4 to 7% in patients with myeloid or lymphoid blast CML and Ph+ ALL.
In clinical trials in CML, drug discontinuation for drug-related adverse reactions was observed in 2.4% of newly diagnosed patients, 4% of patients in late chronic phase after failure of interferon therapy,4% of patients in accelerated phase after failure of interferon therapy and 5% of blast crisis patients after failure of interferon therapy.
However, the occurrence of cytopenias was also clearly dependent on the stage of the disease, the frequency of grade 3 or 4 neutropenias(ANC< 1.0 x 109/ l) and thrombocytopenias(platelet count< 50 x 109/ l)being between 4 and 6 times higher in blast crisis and accelerated phase(59- 64% and 44- 63% for neutropenia and thrombocytopenia, respectively) as compared to newly diagnosed patients in chronic phase CML 16.7% neutropenia and 8.9% thrombocytopenia.