Examples of using Ipscs in English and their translations into Hebrew
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Colloquial
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Ecclesiastic
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Computer
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Programming
The study of iPSCs remains at the cutting edge of biological and clinical research.
Importantly, ASD hasbeen a challenging disease to model using iPSCs because of its complexity.
The iPSCs generated from FLSs can be further used as a tool to study the pathophysiology of RA in the future.
As a major player in the pathogenesis of RA,FLSs can be used as a material to generate and investigate the iPSCs of RA patients.
One of the top defective pathways in the iPSCs was the Wnt signaling pathway, which plays an important role in neuronal development.
However, genetic correction or treatment with a compound that inhibits theWnt signaling pathway restored the ability of the iPSCs to turn into cortical neurons.
The concept of iPSCs shows that we can essentially push this stone back up to the top of the hill so we can reacquire all its decisions again.”.
The main point of this study is that we have found anepigenetic biomarker that can help us distinguish iPSCs that have a diminished capacity for differentiation.
In human iPSCs, two of the genes with the greatest expression increase play a role in suppressing the movement of LINE-1 retrotransposons.
When the scientists took images of the mice retinas, they found that the iPSCs, regardless of injection location, engrafted and repaired blood vessel structures in the retina.
Verfaillie and Philip Van Damme of the Leuven Research Institute for Neuroscience andDisease explore this approach in the study by creating iPSCs from three patients carrying a GRN mutation.
In particular, patient-specific iPSCs can be used as a pioneering tool for the study of disease pathobiology, since iPSCs can be induced from the tissue of any individual.
The technique uses cells from a patient's skin togenerate induced pluripotent stem cells(iPSCs), which are capable of developing into various types of mature tissues- including blood.
It is the ability of iPSCs to differentiate to other cell types that makes them so valuable for laboratory research, however not all iPSCs offer the same differentiation capacity, some cell lines are markedly defective.
These skin cells were then grown in a dish andenticed to become induced pluripotent stem cells(iPSCs) before becoming neural progenitor cells- stem cells that reside in the developing brain.
In this study, the team were looking for a particular type of methylation that only occurs in stem cells, known as non-CG methylation, tosee if they could identify a link between non-CG methylation and differentiation capacity of iPSCs.
Support is growing for building a large bank of iPSCs that scientists around the world can access,” says Zambidis, although large resources and intense quality-control would be needed for such a feat.
Mark Tuszynski and Paul Lu of the University of California, San Diego,sought to circumvent this need for immunosuppression by using iPSCs, which can be derived from a patient's own skin and, eventually, autotransplanted.
But they also found 1,375 genes in human iPSCs with increased levels of expression and 1,050 different genes in chimpanzee and bonobo iPSCs with increased activity.
Two Japanese scientists, Nobel laureate Shinya Yamanaka and Kazutoshi Takahashi, showed, in 2006, that introduction of four genes in skin cells can reprogram fibroblasts into functional embryonic stem-like cellsalso termed“induced pluripotent stem cells”(“iPSCs”).
These findings are particularly important given growing controversy in the scientific literature about whether subtle differences between iPSCs and ESCs should dampen enthusiasm for iPSCs to serve as an alternative source of differentiated precursor cells for various tissues, such as the liver, lung or blood.
Scientists from the RIKEN Research Centre for Allergy and Immunology in Yokohama, Japan, explained in the journalCell Stem Cell(January 2013 issue)how they managed to make cancer-specific immune system cells from iPSCs(induced pluripotent stem cells) to destroy cancer cells.
Using human induced pluripotent stem cells(iPSCs) to model autism spectrum disorder(ASD), researchers at the University of São Paulo, Brazil and University of California, San Diego have revealed for the first time that abnormalities in the supporting cells of the brain, called astrocytes, may contribute to the cause of the disorder.
The research team hope that not only will their discovery be used in the short-term as an efficient analysis method of cell lines for research purposes but, going forward, findings can be used as a starting point for discovering thedevelopmental processes associated with methylation patterns in iPSCs.