Examples of using Ipscs in English and their translations into Russian
{-}
-
Official
-
Colloquial
In addition, the derivation of iPSCs is not repetitive.
In the study, iPSCs were differentiated as a monolayer.
A growing number of research groups have employed iPSCs to model CVDs.
In the same year,human iPSCs were also successfully established 21.
In the most recently, RNA was also successfully applied to generate iPSCs 58.
IPSCs could be obtained by the cells rejuvenation of even centenarians.
A number of genetic cardiomyopathies have also been studied using iPSCs 25.
Furthermore, it seems that iPSCs derived progenies retain tumorigenic potential too 103.
Common to ESCs,the tumorigenicity is also an obstacle preventing the further application of iPSCs.
On the other hand, iPSCs have already been used in the drug screening for disease treatment 106,107.
As ESC-like state cells,the advantages of ESCs in cardiac regeneration are manifested in iPSCs too.
Disease-specific iPSCs and their derivates would exhibit at least partial phenotype of the disease.
By present, this appears to be the most successful application of iPSCs in cardiac tissue engineering 101,102.
At present, the iPSCs have been beginning contributing to the treatment of cardiovascular and other diseases.
Within adult murine models of myocardial infarction,undifferentiated iPSCs were intramyocardial delivered by needle injection.
But in the study, iPSCs showed a delayed and less efficient differentiation of beating EBs compared with ESCs.
Comparison between in vitro and in vivo studies may indicate that researchers are more cautious about in vivo application of iPSCs.
IPSCs are expected to give the opportunity to replace the sick or lost cells directly into the tissues, regenerating the body literally by cells.
Like the in vitro studies,the in vivo application of iPSCs in cardiac tissue regeneration and engineering also adopt a similar route as that of ESCs.
These iPSCs can then in turn be differentiated into any cell type including neurons, cardiac cells, pancreatic cells, liver cells, blood cells or enterocytes.
Closely behind, another independent group in America also successfully derived mouse iPSCs with the same set of factors and further, they obtained live chimeric mice 20.
In less than 5 years, iPSCs were successfully derived in many other species, including rhesus, pig, rat, canine, rabbit, Sheep; bovine Table 1.
This review will discuss the achievements and current status in this field, including development of iPSC derivation,in vitro strategies for cardiac generation from iPSCs, cardiac application of iPSCs, challenges confronted at present as well as perspective in the future.
Under suitable conditions, iPSCs could long-term propagate in undifferentiated state or differentiate into many other cell types, including functional cardiomyocytes 16,17.
By overexpressing the transcription factors, Oct4, Sox2, Klf4, and c-Myc in adult human fibroblasts, Takahashi andYamanaka successfully generated human iPSCs with the capacity to expand and differentiate into all mammalian cell lineages, similar to embryonic stem cells(ESCs) 30.
The iPSCs can be obtained from reprogrammed somatic tissues(fibroblasts) of PD patients themselves[13], which rule out ethical problems and ensures the genetic identity of the transplanted cells and the recipient tissues.
Following transplantation into infarcted non-diabetic mice, iPSCs generated from H9c2 cells can inhibit apoptosis and differentiate into cardiac myocytes, Yan et al.
Application of iPSCs for in vitro modeling of cerebral structures, including BBB, opens new opportunities for development of patient-specific screening of drugs, and for the assessment of individual features in the pathogenesis of central nervous system disorders.
Given that iPS cells can be derived from patients themselves,it had been considered that iPSCs provided a possibility to overcome problems of immunological rejection associated with cell transplantation.
These protocols begin with iPSCs generated that use the traditional retroviral vectors to introduce reprogramming factors; however, these cells have also been noted to retain a small risk for tumor formation despite differentiation towards a cardiac lineage 34.