Examples of using Second-line in English and their translations into Hindi
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Second-line drugs are much newer.
It was long considered a second-line drug.
If one second-line agent fails then another should be tried before moving on to third-line agents.
Is active against CMV but is more toxic and therefore used as a second-line agent.
Mycophenolate mofetil is used as a second-line agent but the evidence base is less good.
This is MDR-TB that has also become resistant to three or more of the six classes of second-line drugs.
Second-line agents- various agents have been used and the current guidance is to use the following.
Extensively drug-resistant TB is also resistant to three or more of the six classes of second-line drugs.
Drug treatment is considered second-line and should not be used in preference to psychological therapy.
India has estimated 135,000 casesof RR/MDR-TB cases but has only put 26,966 patients on second-line drugs;
One of them said,“Second-line injectables are quite useful, let's give them for two months, or let's give them for six”.
FOLFOX as first-line treatment,then FOLFIRI(= folinic acid plus fluorouracil plus irinotecan) as second-line treatment; or.
Foscarnet and cidofovir are second-line therapeutic options- unless ganciclovir resistance has been demonstrated.
The old case definition of XDR-TB is MDR-TB that is also resistant to three or more of the six classes of second-line drugs.
Androgens(eg, danazol) can be used as second-line, but have significantly more potential for adverse effects, interactions and contra-indications.
Cabozantinib also demonstrated an overall survival benefit over everolimus andwas approved by the FDA as a second-line treatment in 2016.
Once a patient's HIV virus is resistant to first-line drugs,then second-line drugs that cost more but have more side effects are treated.
The quoted figures of long-term survival withsuccessful first-line therapy are in the order of 60% which fall to 20-35% with second-line agents.
Before this study, the second-line treatment was the anti-convulsant drug phenytoin, but until now this practice had never been scrutinised in a robust, major randomised controlled trial.
FOLFOX(= folinic acid plus fluorouracil plusoxaliplatin) as first-line treatment, then single agent irinotecan as second-line treatment; or.
A drug may be classed as second-line instead of first-line for one of three possible reasons: it may be less effective than the first-line drugs; or it may have toxic side-effects; or it may be effective, but unavailable in many developing countries.
Consider routine referral for persistent infections(three or more attacks per year)or persistent symptoms despite an adequate course of second-line antibiotics.
Methylxanthines such as theophylline generally cause more harm than benefit and thus are usually not recommended,but may be used as a second-line agent in those not controlled by other measures.
Naproxen has been shown to be as effective as aspirinand less toxic, but due to the limited clinical experience, naproxen is recommended only as a second-line treatment.
This discovery has led researchers to investigate the potential for cannabis to treat various painconditions for which opioids are currently first- or second-line therapies.
Udwadia first spoke about‘totally drug resistant TB'(TDR-TB) in 2012,when he described his patients who were resistant to all the first- and second-line TB drugs.
It is expected that after 2 years of tenofovir drug costs will also be reduced(because the patent medicine is about to expire, and the domestic generic drugs will come out, the price of generic drugs will drop greatly) and the first-line drugs in China willalso become the mainstream drug for hepatitis B antiviral therapy, Many patients with second-line nucleoside drug efficacy is not high drug-resistant distress will gradually fade away.