Examples of using Transcriptome in English and their translations into Russian
{-}
-
Official
-
Colloquial
CAGE, transcriptome analysis of individual cells, open chromatin.
The first attempts to study whole transcriptomes began in the early 1990s.
Thus, AS results in mRNA diversity forming a cell transcriptome.
Transcriptome analysis was performed using Affymetrix DNA microarray HGU133A series.
Processing NGS data- assembling andvisualisation of genomes, transcriptomes, ChiP-Seq.
Transcriptomes of different disease states, tissues, or even single cells are now routinely generated.
Trans-ABySS(Assembly By Short Sequences) is a software pipeline written in Python andPerl for analyzing ABySS-assembled transcriptome contigs.
Human Transcriptome Array 2.0(Affymetrix) has probes for 260,488 junctions; each junction is covered by four probes with a spacing of 2 bases 35.
Despite the growinguse of RNA-sequencing technology, DNA-microarrays remain essential transcriptome research tool.
The first attempt at capturing a partial human transcriptome was published in 1991 and reported 609 mRNA sequences from the human brain.
Early studies determined suitable thresholds empirically, butas the technology matured suitable coverage was predicted computationally by transcriptome saturation.
SeqMan NGen, part of DNASTAR's software pipeline, includes a de novo transcriptome assembler for small or large transcriptome data sets.
Unlike micF RNAbeing discovered by accident, the majority of asRNAs were discovered by genome wide searches for small regulatory RNAs and by transcriptome analysis.
The ability of RNA-seq to analyze a sample's whole transcriptome in an unbiased fashion makes it an attractive tool to find these kinds of common events in cancer.
Transcriptome analysis of three cell types- epitheliocytes, fibroblasts and endothelial cells- revealed cell type-specific AS patterns persisting independently of the tissue of origin.
Transcriptomics technologies are the techniques used to study an organism's transcriptome, the sum of all of its RNA transcripts.
In 2008, two human transcriptomes, composed of millions of transcript-derived sequences covering 16,000 genes, were published, and by 2015 transcriptomes had been published for hundreds of individuals.
Unlike the genome, which is roughly fixed for a given cell line(excluding mutations), the transcriptome can vary with external environmental conditions.
Currently, most researches concerning SC transcriptome are focused on the dynamics of total gene expression during SC differentiation and pluripotent state maintenance 94-98.
Difficult process of the purification and confirmation of the authentic features of the stem cells resulted in absence of the systematic,detailed meta-analysis of the transcriptome profiles of the cancer stem cell.
GeneNote and GeneAnnot for transcriptome analyses, GeneLoc for genomic locations and markers, GeneALaCart for batch queries and GeneDecks for finding functional partners and for gene set distillations.
Similarly, genes that function in the development of cardiac, muscle, andnervous tissue in lobsters were identified by comparing the transcriptomes of the various tissue types without use of a genome sequence.
Single-cell transcriptomes are now well described andhave even been extended to in situ RNA-Seq where transcriptomes of individual cells are directly interrogated in fixed tissues.
For certain types of cancer, like in colorectal and prostate, the number of splicing errors per cancer has been shown to vary greatly between individual cancers,a phenomenon referred to as transcriptome instability.
SOAPdenovo-Trans is a de novo transcriptome assembler inherited from the SOAPdenovo2 framework, designed for assembling transcriptome with alternative splicing and different expression level.
Possibly in the future not only trophectoderm biopsy will be carried out, but also blastocentesis, the study of the media for cultivation, possibly not only autosomal diseases will be connected but also monogenic diseases, mitochondrial,as well as the study of telomere length, transcriptome and micro RNA.
Transcriptome research is conducted in two directions: 1 assessment of the total mRNA level of a gene(gene expression); 2 analysis of composition and quantitative distribution of mature mRNA spliced isoforms.
Due to the ability of alternative sequencing methods to achieve a greater read length(and therefore being more suited to whole genome analysis) this technology may be best suited to small scale applications such as microbial genome sequencing,microbial transcriptome sequencing, targeted sequencing, amplicon sequencing, or for quality testing of sequencing libraries.
Despite high density of transcriptome coverage the microarray has a number of disadvantages: 1 relatively short probe length enhances cross hybridization probability; 2 high heterogeneity of probes results in a wide range of signal intensity, and complicates data analysis[10]; 3 inability to detect relatively small(less than 25 bases) 5'- and 3'-splicing sites shifts See Figure 1(d) and e.