Examples of using Gabapentin in English and their translations into Vietnamese
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What other drugs will affect gabapentin.
Gabapentin is also used to treat certain types of long-lasting pain caused by damage to nerves.
The active substance in Neurontin is gabapentin.
It is not necessary to monitor gabapentin plasma concentrations to optimise gabapentin therapy.
Acute, life-threatening toxicity has not been observed with gabapentin overdoses of up to 49g.
Gabapentin pharmacokinetics in children were determined in 50 healthy subjects between the ages of 1 month and 12 years.
Other medications that might be prescribed include gabapentin(gralise, neurontin) and topiramate(topamax, qudexy xr).
Gabapentin works in the brain to prevent seizures and relieve pain for certain conditions in the nervous system.
Ethanol and agents that affect the central nervoussystem may increase the side effects of gabapentin from the central nervous system.
Doctors may prescribe gabapentin(Neurontin®), pregabalin(Lyrica®) or another anticonvulsant to help control burning and pain.
The concentration of phenytoin in the blood can increase phenylbutazone, felbamate,diltiazem, gabapentin and cimetidine, in some cases this is accompanied by the development of a toxic effect.
Gabapentin was given in the diet to mice at 200, 600, and 2000 mg/kg/day and to rats at 250, 1000, and 2000 mg/kg/day for 2 years.
Effect of long-term treatment(more than 36 weeks) gabapentin on learning, intelligence, and development of the child is not sufficiently studied.
If gabapentin is discontinued and/or an alternate anticonvulsant medication is added to the therapy, this should be done gradually over a minimum of 1 week.
Phenibut and analogues at biological targets[8][2] Compound α2δ GABAB Phenibut ND 177(R)-Phenibut 2392(S)-Phenibut 39gt;1,000 Baclofen 156 6 Gabapentin 0.05gt;1,000 Values are Ki(μM) in rat brain.
Certain anti-seizure medications, including gabapentin(Gralise, Horizant, Neurontin) and pregabalin(Lyrica), can lessen the pain of postherpetic neuralgia.
It was studied for neuropathic pain in 2005 by Winkler et al., with good results: it had minimal effects on motor coordination and alertness at effective doses,and appeared to be equally effective as gabapentin.[7].
A number of other medicines, including gabapentin(Neurontin), tramadol(Ultram) and tizanidine(Zanaflex), are being investigated for the treatment of fibromyalgia.
Two mainstays in treating nerve pain in the feet include the antidepressant amitriptyline(Elavil), which increases the levels of brain chemicals that ratchet down pain signals,and the anticonvulsant gabapentin(Neurontin), which apparently works by interfering with nerve signaling involved in pain as well as seizures.
In accordance with current clinical practice, if gabapentin has to be discontinued it is recommended this should be done gradually over a minimum of 1 week independent of the indication.
No significant pharmacokinetic interactions were observed between levetiracetam or its major metabolite and concomitant medications.[28] The pharmacokinetic profile of levetiracetam is not influenced by phenytoin, phenobarbital, primidone, carbamazepine, valproic acid,lamotrigine, gabapentin, digoxin, ethinylestradiol, or warfarin.
The identification and function of the gabapentin binding site remains to be elucidated and the relevance of these various actions to the anticonvulsant effects remains to be established.
Gabapentin binds with high affinity to the α2δ(alpha-2-delta) subunit of voltage-gated calcium channels and it is proposed that binding to the α2δ subunit may be involved in gabapentin's anti-seizure effects in animals.
A 2010 study following 297,620 new patients treated with an anticonvulsant found that certain drugs,including gabapentin, lamotrigine, oxcarbazepine and tiagabine, were associated with a higher risk of suicidal acts or violent deaths.
Gabapentin binds with high affinity to the α2δ(alpha-2-delta) subunit of voltage-gated calcium channels and it is proposed that binding to the α2δ subunit may be involved in gabapentin's anti-seizure effects in animals.
Examples of recently approved prodrugsare such as dabigatran etexilate(approved in 2010), gabapentin enacarbil(2011), sofosbuvir(2013), tedizolid phosphate(2014), isavuconazonium(2015), aripiprazole lauroxil(2015), selexipag(2015), and latanoprostene bunod(2017).
Zolpidem and gabapentin, which are GABA-agonists, have been shown to benefit patients suffering from Parkinson's disease, while vigabatrin(gamma-vinyl-GABA), another GABA-agonist, has provided benefits for tardive dyskinesia and a variety of other movement disorders.
That weakening of self-control-related circuits makes it even harder for people to resist drugcravings when they're trying to quit, but gabapentin may help restore those circuits, by reducing stress and enabling patients to sleep better, so that they function better while awake," said study author Barbara J. Mason.
Gabapentin- Chemical Structure Gabapentin was synthesized with the aim of creating an active ingredient capable of exerting an agonist action against gamma-aminobutyric acid receptors(GABA), one of the most important neurotransmitters inhibiting the central nervous system.
Gabapentin did not increase the incidence of malformations, compared to controls, in the offspring of mice, rats, or rabbits at doses up to 50, 30 and 25 times respectively, the daily human dose of 3600 mg,(four, five or eight times, respectively, the human daily dose on a mg/m2 basis).