Examples of using Noncoding in English and their translations into Portuguese
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Another noncoding polymorphism is a VNTR in the second intron STin2.
Implementation of computational approaches for identification of long noncoding RNAs….
These noncoding DNA variants may be in the form of duplications or deletions.
The proportion of coding versus noncoding DNA varies significantly between species.
One comparative study that looked at more than 300 prokaryotic and30 eukaryotic genomes estimated the minimum amount of noncoding DNA that a eukaryotic organism requires.
An abundant form of noncoding DNA in humans are pseudogenes, which are copies of genes that have been disabled by mutation.
Recruitment of polycomb repressive complex 2 by intronic long noncoding RNA ANRASSF1… Biochemistry.
Some of this noncoding DNA is used to produce non-coding RNA components such as transfer RNA, regulatory RNA and ribosomal RNA.
In addition to mutations of genes,the inheritance of changes in noncoding DNA or junk DNA is also a key player in this game.
Some regions of the noncoding DNA may also be essential for chromosome structure, the function of centromeres and play a role in cell division meiosis.
Micrornas(mirnas) are a group of small rna molecules containing from 19 to 25 nucleotides of noncoding protein with fundamental action in the regulation of gene expression.
Mirnas are small noncoding rnas with approximately 20-24 nucleotides in length and in humans, mirnas have been also associated with pregnancy complications.
This niche specificity may be related to different regulation of the expression of virulence factors between different species,which can be played by noncoding RNAs.
Increasingly, long noncoding rnas(lncrnas) emerge as important regulators of cell biology, especially in differentiation processes during development.
Recent analyses of the human and animal genomes have shown that mostof RNA transcripts do not code for proteins(i.e. they are messenger RNAs or mRNAs), but are instead noncoding RNAs ncRNAs.
Despite often being noncoding DNA, some ultra-conserved elements have been found to be transcriptionally active, giving non-coding RNA molecules.
Anti-HCV-positive samples were tested for of viral RNA by real-time polymerase chain reaction real-time PCR using primers complementary to the 5' noncoding region of the HCV genome.
Synonymous substitutions andmutations affecting noncoding DNA are often considered silent mutations; however, it is not always the case that the mutation is silent.
The sequenced region of mete covered 3,890pb, where 2,298pb correspond to the coding region(composed of 11 exons)and 1,592pb to the noncoding region comprising 10 introns and a portion of 3'utr.
Microrna are small noncoding rna with approximately 19-25 nucleotides that act as regulators of gene expression and may act in the control of many biological processes.
About a third of ASD is due to de novo mutations, butthe remaining risk is now explained at least partially by the occurrence of rare inherited variants in noncoding DNA sequences. Noncoding DNA Variants.
The reasons for the presence of so much noncoding DNA in eukaryotic genomes and the extraordinary differences in genome size, or C-value, among species, represent a long-standing puzzle known as the"C-value enigma.
Most laboratories use typing based mtdna polymorphisms in the nucleotide sequence in the noncoding region(also known as the control region, the hypervariable or d-loop) of mtdna.
Almost 98% of the DNA in humans is apparently noncoding, but it is far from useless because it comprises of regulatory elements that switch genes on or off, regulate transcription and may have numerous other roles as well.
Molecular evolution of hox genes entails signatures in regulatory regions that potentially affect gene expression, such as the cis-regulatory elements(cres)that surround the hoxd cluster and its noncoding rnas ncrnas.
The RNA polymerase, and with it the transcription bubble,travels along the noncoding strand in the opposite, 3' to 5', direction, as well as polymerizing a newly synthesized strand in 5' to 3' or downstream direction.
Samples positive for HCV RNA were genotyped using the line probe assay INNO-LiPA, Versant HCV Genotype Assay, Innogenetics, Belgium,which uses biotinylated primers complementary to the 5' noncoding region of the HCV genome.
Though this was not necessarily unexpected due to previous decades of research discovering many functional noncoding regions, some scientists criticized the conclusion for conflating biochemical activity with biological function.
A class of small noncoding rnas, known as micrornas(mirnas), represses the expression of target mrnas, and many studies demonstrate that mir-1, mir-133, mir-206 and mir-499 regulate different processes in skeletal muscle through the mrna silencing of hdac4, srf, pax7 and sox6, respectively.
The three aims in this proposal are(1) to determine novel long noncoding RNAs expressed in pancreatic cancer using RNA-seq data,(2)to detect somatic mutations in noncoding regions and to identify significantly mutated noncoding genes using WGS data from TCGA,(3) to determine cases where somatic mutations in noncoding RNA regions disrupted the expression of neighboring genes.