Examples of using Noncoding in English and their translations into Vietnamese
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Human genomes include both protein-coding DNA genes and noncoding DNA.
It focused on noncoding molecules that have been puzzling scientists for a long time.
Individual genomes contain both protein-coding DNA enzymes and noncoding DNA.
Over 98% of the human genome is noncoding DNA, meaning it doesn't get translated into proteins.
The gene spans approximately 20 kb andcontains 20 exons with first exon being noncoding.
The MAYV RNA genome contains the 5' untranslated region,3' noncoding region, and two open reading frames(ORFs).
Some of this noncoding DNA has known functions, but much of it has no known function and is called"Junk DNA".
And I discovered that telomeres consisted of special segments of noncoding DNA right at the very ends of chromosomes.
Regulation of genes by noncoding DNA might help explain the complex interplay between our environment and genetic expression.
Deep within the genetic heart of all our cells are telomeres,or repeating segments of noncoding DNA that live at the ends of the chromosomes.
Noncoding RNA has long remained mysterious, but little by little researchers have been uncovering the fact that it is not devoid of function.
A large portion of this so-called noncoding DNA controls the expression of genes, switching them on and off.
Twice every week, they injected the mice with locked nucleic acid antisense oligonucleotides,an agent that blocks the action of relevant noncoding RNA.
But there is another type of RNA known as“noncoding RNA” that is not involved in the protein synthesis process.
Researchers from Sahlgrenska Academy at the University of Gothenburg in Sweden have conducted ameticulous project investigating the role of long noncoding RNA in the development of cancer tumors.
More than 98 percent of our genome is noncoding DNA- DNA that doesn't contain information to make proteins.
Since there is a strong link between cell division cycle and cancer," says Kanduri,"we areusing it as the basis for identifying the important long noncoding RNA molecules that play a key role in cancer growth.".
The 5' proximal and3' proximal ORFs are separated by a short, noncoding sequence and represent two-thirds and one-third of the genomic RNA, respectively.
Some of the key topics that spurred development of the field have been the evolution of enzyme function, the use of nucleic acid divergence as a"molecular clock" to study species divergence,and the origin of noncoding DNA.
This function also implicates noncoding RNA in the development and growth of cancer tumors, allowing certain cells to multiply abnormally.
Thus we have identified a new method, optimized it in a lab environment,and identified long noncoding RNA molecules that are involved in uncontrolled cell division.
People used to call the noncoding regions‘junk DNA', but I see it as a jungle that has not been explored,” said neurobiologist Christopher Gregg from the University of Utah.
In the new study, Chandrasekhar Kanduri- a professor of medical biochemistry and cell biology-and colleagues saw that by downregulating noncoding RNA activity, they were able to reduce tumor growth in a mouse model of lung cancer by 40 to 50 percent.
Previously, scientists thought that these“noncoding” genes, called pejoratively,“junk DNA,” which means they do not instruct the body in the making of proteins, had no purpose at all.
Finally, in addition to monitoring messenger RNA levels, which encode protein-making instructions, the researchers were also able to detect other types of RNA-such as long, noncoding RNA and circular RNAs- that are likely to play significant regulatory roles within the cell.
According to Kanduri,"This link[between noncoding RNA and cancer] is known, but no one has made such a broad and extensive analysis previously, nor examined long noncoding RNAs so specifically.".
Russell, Boliar and their colleagues wanted to investigate what cellular mechanisms were at play that helped keep infected macrophages alive,and the researchers turned their attention to long noncoding RNAs(lncRNAs)- genetic coding elements that turn genes up or down, but do not translate directly into proteins themselves.
The reasons for the presence of so much noncoding DNA in eukaryotic genomes and the extraordinary differences in genome size, or C-value, among species, represent a long-standing puzzle known as the"C-value enigma".
To prove this theory,the team blocked SAF's action using another noncoding RNA called small interfering RNA(siRNA), which effectively degrades targeted RNAs such as SAF.
Recent results indicate that most of the vast quantities of noncoding DNA within the genome have associated biochemical activities, including regulation of gene expression, organization of chromosome architecture, and signals controlling epigenetic inheritance.