Examples of using Glucuronidation in English and their translations into Slovak
{-}
-
Medicine
-
Colloquial
-
Official
-
Financial
-
Ecclesiastic
-
Official/political
-
Computer
-
Programming
Due to increased glucuronidation.
Perampanel is extensively metabolised via primary oxidation and sequential glucuronidation.
Presystemic glucuronidation is extensive.
Medicinal products metabolised by glucuronidation.
Glucuronidation is the main metabolic pathway for deferasirox, with subsequent biliary excretion.
Medicinal products metabolised by glucuronidation(UGT1A1).
Glucuronidation and renal excretion are the main mechanisms of elimination in CYP2D6 poor metabolisers.
Other inducers of CYP3A4 activity and/ or glucuronidation e. g.
Emtricitabine did not inhibit the glucuronidation reaction of a non-specific UGT substrate in vitro.
After the treatment, EMEND causes a transient mild induction of CYP2C9,CYP3A4 and glucuronidation.
In vitro, sorafenib inhibited glucuronidation via UGT1A1 and UGT1A9.
Cobicistat is metabolised via CYP3A and/or CYP2D6-mediated oxidation anddoes not undergo glucuronidation.
A small percentage of vitamin D3 undergoes glucuronidation prior to elimination.
Oxidation by CYP3A and glucuronidation by UGT2B7 appear to be the major pathways of cobimetinib metabolism.
Table 6: Effects of other medicinal products on glucuronidation of lamotrigine.
The main metabolic pathway is glucuronidation of entacapone and its active metabolite, the cis-isomer, which accounts for about 5% of plasma total amount.
Abacavir, Zidovudine:Concentrations may be reduced due to increased glucuronidation by Kaletra.
Interaction with indinavir/ ritonavir not studied Ritonavir induces glucuronidation and as a result is expected to decrease the plasma concentrations of atovaquone.
The predominant metabolic pathways ofexcreted radioactivity are hydroxylation with subsequent glucuronidation, or hydrolysis.
In vitro, ospemifene and 4-hydroxyospemifene inhibited glucuronidation via UGT1A3 and UGT1A9 at clinically relevant concentrations.
Secondary biotransformation pathwaysinvolving the primary biotransformation products included glucuronidation and dehydrogenation.
The main metabolic processes are demethylenation and glucuronidation, although precise identification of the enzymes involved has not yet been achieved.
The oxidative metabolism of laropiprant is catalysed primarily by CYP3A4, whereas several UGT isoforms(1A1, 1A3, 1A9 and 2B7) catalysed the acyl glucuronidation.
UGT1A3 and UGT2B7 are involved in the glucuronidation of the active metabolite.
Patients with deficient glucuronidation of bilirubin, such as those with Gilbert's syndrome, may be at greater risk of myelosuppression when receiving therapy with ONIVYDE.
Bimatoprost then undergoes oxidation, N-deethylation and glucuronidation to form a diverse variety of metabolites.
Aromatic and aliphatic hydroxylation or glucuronidation metabolites are present in very low levels, display considerably lower anti-HIV activity and do not contribute to the overall antiviral activity of elvitegravir.
Medicines that stimulate the metabolising proteins called CYP3A4 ora metabolising process called glucuronidation(e.g. rifampicin, rifabutin, carbamazepine, phenytoin or St John's Wort).
As a mild inducer of CYP2C9, CYP3A4 and glucuronidation, aprepitant can decrease plasma concentrations of substrates eliminated by these routes within two weeks following initiation and treatment.