Examples of using Multiple dosing in English and their translations into Slovak
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Multiple dosing of perampanel.
Similar inhibition was seen following single and multiple dosing.
Multiple dosing does not cause marked drug accumulation.
This indicates no time-dependency in the kinetics of alogliptin after multiple dosing.
Multiple dosing does not cause marked medicinal product accumulation.
Due to its long elimination half-life, piperaquine accumulates after multiple dosing.
Multiple dosing does not result in plasma accumulation of prednisolone.
No notable increase in Cmax and AUC upon multiple dosing(10 mg/ kg three times daily) was observed.
Upon multiple dosing, there is an accumulation of immunoreactive interferons.
(Mean time to maximum concentration(mean Tmax)is 4 hours after multiple dosing).
Upon multiple dosing exposure increased by an accumulation factor of 1.3 to 2.3.
(Mean time to maximum concentration(mean Tmax)is 4 hours after multiple dosing).
On multiple dosing, Lisinopril has an effective half-life of accumulation of 12.6 hours.
As a result of the short half- life, 1.8± 0.4 hours,only a minimal increase in plasma concentrations occurred after multiple dosing.
Upon multiple dosing Cmax and AUC increased in approximate proportion to lomitapide dose. .
The pharmacokinetics of single andmultiple doses of simvastatin showed that no accumulation of drug occurred after multiple dosing.
After multiple dosing, less than 3% of the lopinavir dose is excreted unchanged in the urine.
In asthmatic children, approximately 6% of the dose was recovered in the urine as unchanged formoterol after multiple dosing of 12 and 24 micrograms.
On multiple dosing there is no marked accumulation, with steady state exposures achieved within~3 to 4 days.
Mean steady-state exposure(AUCtau)of unboosted elvitegravir is~ 20% lower after multiple dosing versus a single dose, indicating modest autoinduction of its metabolism.
Multiple dosing of Nexavar for 7 days resulted in a 2.5- to 7-fold accumulation compared to single dose administration.
Similar CST½ values were observed following both single and repeated administration demonstrating that there is a predictable andconsistent duration of action after multiple dosing of the sublingual tablet.
Upon multiple dosing, ribavirin accumulates extensively in plasma with a six-fold ratio of multiple-dose to single-dose AUC12hr.
Upon multiple dosing, plasma concentrations of bosentan decrease gradually to 50%- 65% of those seen after single dose administration.
Multiple dosing of dapoxetine(60 mg/day for 6 days) did not affect the pharmacokinetics or pharmacodynamics of a single 5 mg dose of glyburide.
Upon multiple dosing, plasma concentrations of bosentan decrease gradually to 50%- 65% of those seen after single dose administration.
After multiple dosing, the mean concentrations of the demethyl and didemethyl metabolites are usually 28- 31% and<5%, respectively, of the escitalopram concentration.
Upon multiple dosing, ribavirin accumulates extensively in plasma with a six-fold ratio of multiple- dose to single-dose AUC12hr.
Following multiple dosing in patients, modified-release levodopa/carbidopa had reduced fluctuations in levodopa plasma concentrations with peak-to-trough fluctuation index of 1.5 with minimal accumulation of levodopa.