Examples of using Multiple dosing in English and their translations into German
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Multiple dosing does not cause marked drug accumulation.
This indicates no time-dependency in the kinetics of alogliptin after multiple dosing.
Multiple dosing does not cause marked medicinal product accumulation.
The estimated apparent half-life is 50 to 60 hours,which is in line with the accumulation observed after multiple dosing.
Multiple dosing of 7,200 mg/ day was associated with no major signs or symptoms.
Anavar only has a half-life of 10 hours, and multiple dosing is recommended for it's only actually effective for 5 hours as estimated.
On multiple dosing there is no marked accumulation, with steady state exposures achieved within~3 to 4 days.
At a dose of 10 mg/kg, mean Vss averaged between 133(SD 24)ml/kg after multiple dosing, corresponding to a value of approximately 10 l for a 75 kg person.
Upon multiple dosing Cmax and AUC increased in approximate proportion to lomitapide dose. .
Multiple dosing of Nexavar for 7 days resulted in a 2.5- to 7-fold accumulation compared to single dose administration.
Kcal/33% fat,suggesting that meal content has less effect on nelfinavir exposures during multiple dosing than would be anticipated based on data from single dose studies.
Hours with average time of 28 hours, and is characterized by dose dependent pharmacokinetic which meansthat AUC and Cmax increase in proportion to each other with multiple dosing.
Conclusion: These results suggest that dual topical glaucoma therapy with multiple dosing can in many cases be replaced by latanoprost monotherapy with once daily administration.
Similar CST½ values were observed following both single and repeated administration demonstrating that there is a predictable andconsistent duration of action after multiple dosing of the sublingual tablet.
In HIV-infected patients(n=13), multiple dosing of REYATAZ 400 mg(without ritonavir) once daily with food produced a geometric mean(CV%) for atazanavir Cmax of 2298(71) ng/ml, with time to Cmax of approximately 2.0 hours.
The prolonged half-life(50 hours) results in the maintenance of relatively stable plasma concentrations throughout the day on once daily doses andto significant accumulation upon multiple dosing.
After multiple dosing of ritonavir to healthy volunteers(500 mg twice daily) and subjects with mild to moderate hepatic impairment(Child Pugh Class A and B, 400 mg twice daily) exposure to ritonavir after dose normalisation was not significantly different between the two groups.
In vitro studies showed that rasagiline at a concentration of 1 µg/ml(equivalent to a level that is 160 times the average Cmax~ 5.9-8.5 ng/ml in Parkinson'sdisease patients after 1 mg rasagiline multiple dosing), did not inhibit cytochrome P450 isoenzymes, CYP1A2, CYP2A6, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4 and CYP4A.
Cobicistat 150 mg multiple doses.
Digoxin(0.5 mg single dose)/Cobicistat 150 mg multiple doses.
Pharmacokinetic Parameters at Multiple Dose Levels after a Single Infusion of Oxyglobin.
However the effect of multiple doses is not known.
Elimination half-life In plasma single and multiple doses.
Each pen contains multiple doses.
Single dose versus multiple doses.
For instance, smaller dogs usually need multiple doses of insulin as part of their daily insulin therapy, while larger dogs may only need one dose per day.
Tigecycline shows a polyexponential elimination fromserum with a mean terminal elimination half-life after multiple doses of 42 hours although high interindividual variability exists.
Steroid cycles require consuming multiple doses of steroids in a fixed period of time of time, then stoppingfor a period of time, and starting again.
The researchers administered multiple doses of cells to a damaged heart throughout a four-week period.