Примери за използване на Multiple dosing на Английски и техните преводи на Български
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Similar inhibition was seen following single and multiple dosing.
Multiple dosing does not result in plasma accumulation of prednisolone.
The pharmacokinetics are linear following single and multiple dosing.
Upon multiple dosing, there is an accumulation of immunoreactive interferons.
Due to its long elimination half-life, piperaquine accumulates after multiple dosing.
Upon multiple dosing exposure increased by an accumulation factor of 1.3 to 2.3.
This indicates no time-dependency in the kinetics of alogliptin after multiple dosing.
Multiple dosing of 7,200 mg/day was associated with no major signs or symptoms.
The mean elimination half-life(t1/2)of bortezomib upon multiple dosing ranged from 40-193 hours.
Following multiple dosing of 5, 10, or 20 mg/day, mean Cmax values of 9 to 33 ng/mL were observed.
No notable increase in Cmax and AUC upon multiple dosing(10 mg/ kg three times daily) was observed.
After multiple dosing, less than 3% of the lopinavir dose is excreted unchanged in the urine.
Artenimol is very rapidly absorbed,Tmax being approximately 1-2 hrs after single and multiple dosing.
On multiple dosing there is no marked accumulation, with steady state exposures achieved within~3 to 4 days.
Ertugliflozin does not exhibit time-dependent pharmacokinetics andaccumulates in plasma up to 10-40% following multiple dosing.
No unexpected accumulation in the plasma was observed after multiple dosing at the recommended dose of 100 mg once daily.
The estimated apparent half-life is 50 to 60 hours,which is in line with the accumulation observed after multiple dosing.
On multiple dosing, an AUC accumulation ratio of 1.8 was observed and PK appeared to be time-dependent to a small extent.
As a result of the short half-life,1.8± 0.4 hours, only a minimal increase in plasma concentrations occurred after multiple dosing.
Multiple dosing of Nexavar for 7 days resulted in a 2.5- to 7-fold accumulation compared to single dose administration.
Posaconazole exhibits dose proportional pharmacokinetics after single and multiple dosing in the therapeutic dose range(200-300 mg).
Upon multiple dosing, ribavirin accumulates extensively in plasma with a six-fold ratio of multiple-dose to single-dose AUC12hr.
However, this finding was not reproduced consistently in subsequent studies in Japanese orAsian breast cancer patients after multiple dosing.
Upon multiple dosing, plasma concentrations of bosentan decrease gradually to 50-65% of those seen after single dose administration.
The pharmacokinetics of single andmultiple doses of simvastatin showed that no accumulation of medicinal product occurred after multiple dosing.
Multiple dosing has no effect on the pharmacokinetics of either imipenem or cilastatin, and no accumulation of imipenem/cilastatin was observed(see section 4.2).
During multiple dosing of 250 mg every 8 hours for 7 doses, faecal concentrations of vancomycin, in volunteers, exceeded 100 mg/kg in the majority of samples.
Hours after first administration of arsenic trioxide, but due to their longer half-life,accumulate more upon multiple dosing than does AsIII.
If dosed as continuous drinking water medication(multiple dosing) steady-state concentrations of 0.5 mg(turkeys) to 0.8 mg(chicken) enrofloxacin per litre are achieved.