Examples of using Isoforms in English and their translations into Romanian
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Medicine
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Colloquial
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Official
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Ecclesiastic
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Ecclesiastic
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Computer
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Programming
MMAE does not inhibit other isoforms.
CYP isoforms selective substrates.
MTHFR has at least two promoters and two isoforms(70 kDa and 77 kDa).
Two isoforms, COX-1 and COX-2, have been identified.
Inductive effect of tipiracil on human CYP isoforms cannot be excluded.
In vitro, emtricitabine did not inhibit metabolism mediated by any of the following human CYP450 isoforms.
In vitro results indicate that different CYP isoforms are able to catalyse the N-dealkylation of rotigotine.
Rivaroxaban neither inhibits nor induces any major CYP isoforms like CYP3A4.
In vitro, multiple cytochrome P-450 isoforms including CYP3A, CYP2C19/C9 and CYP2D6 are responsible for metabolism of nelfinavir.
Based on in vitro studies, empagliflozin does not inhibit, inactivate, orinduce CYP450 isoforms.
Studies have confirmed that tadalafil does not inhibit orinduce CYP450 isoforms, including CYP3A4, CYP1A2, CYP2D6, CYP2E1, CYP2C9 and CYP2C19.
Furthermore, there's not a lot of information available about the excretion of various human growth hormone isoforms in the urine.
CYP isoforms 2E1, 1A2, 2B6, 2C8, and 2C19 are involved to a lesser extent and isoforms 2D6 and 2C9 are not involved in the metabolism of lomitapide.
It is unlikely that atosiban inhibits hepatic cytochrome P450 isoforms in humans(see section 4.5).
Tadalafil is not expected to cause clinically significant inhibition orinduction of the clearance of medicinal products metabolised by CYP450 isoforms.
Based on in vitro data,nelfinavir is unlikely to inhibit other cytochrome P450 isoforms at concentrations in the therapeutic range.
A large proteomic analysis of frontal cortices from depressed patients showed significant reductions in three GFAP isoforms[39].
Concurrent use of substances which are metabolised by CYP450 isoforms may result in higher or lower plasma levels of either masitinib or those substances.
In vitro evaluation indicated that trifluridine andFTY had no inductive effect on human CYP isoforms(see section 5.2).
In vitro studies suggest that alogliptin does not inhibit norinduce CYP 450 isoforms at concentrations achieved with the recommended dose of 25 mg alogliptin(see section 5.2).
This reduces the possibility of detection by the urine test by lowering the percent of basic isoforms in the urine.
Riociguat and its main metabolite are not inhibitors or inducers of major CYP isoforms(including CYP 3A4) or transporters(e.g. P-gp/BCRP) in vitro at therapeutic plasma concentrations.
In vitro studieshave shown that brivaracetam exhibits little or no inhibition of CYP450 isoforms except for CYP2C19.
Drug-drug interactions involving the major CYP450 and UGT isoforms with empagliflozin and concomitantly administered substrates of these enzymes are therefore considered unlikely.
Oritavancin was found to be a nonspecific, weak inhibitor(CYP2C9 and CYP2C19) or a weak inducer(CYP3A4 and CYP2D6)of several CYP isoforms.
The oxidative metabolism of laropiprant is catalysed primarily by CYP3A4,whereas several UGT isoforms(1A1, 1A3, 1A9 and 2B7) catalysed the acyl glucuronidation.
Based upon in vitro data, chronic administration of vorapaxar is unlikely to induce the metabolism of drugs metabolized by major CYP isoforms.
Neither emtricitabine nor tenofovir inhibited in vitro drug metabolism mediated by any of the major human CYP450 isoforms involved in drug biotransformation.
In vitro studies in human liver microsomes indicate that tigecycline does not inhibit metabolism mediated by any of the following 6 cytochrome P450(CYP) isoforms.
In vitro experiments indicate that telavancin will not affect the clearance of medicinal products metabolised by CYP isoforms 1A2, 2C9, 2C19 and 2D6.