Examples of using Isoforms in English and their translations into Croatian
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Colloquial
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Ecclesiastic
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Computer
Inhibition of CYP isoforms.
There are two isoforms of COX, COX-1, and COX-2.
The cyclo-oxygenase enzyme(COX) is present in two isoforms.
Two isoforms, COX-1 and COX-2, have been identified.
These receptors exist in 2 isoforms, PR-A and PR-B.
In human liver microsomes, abacavir did not inhibit cytochrome P450 isoforms.
In vitro results indicate that different CYP isoforms are able to catalyse the N-dealkylation of rotigotine.
Based on in vitro studies, empagliflozin does not inhibit, inactivate, orinduce CYP450 isoforms.
From the recombinant CYP isoforms investigated in vitro CYP1A1 catalysed formation of riociguat's main metabolite most effectively.
The protein occurs in the plasma in 2 main isoforms, ApoB48 and ApoB100.
In vitro study results demonstrate that ingenol mebutatedoes not inhibit or induce human cytochrome P450 isoforms.
Sildenafil metabolism is principally mediated by the cytochrome P450(CYP) isoforms 3A4(major route) and 2C9 minor route.
In vitro studies demonstrated that neither oseltamivir nor the active metabolite is a substrate for, or an inhibitor of,the major cytochrome P450 isoforms.
It is unlikely that atosiban inhibits hepatic cytochrome P450 isoforms in humans see section 4.5.
Tadalafil is not expected to cause clinically significant inhibition orinduction of the clearance of medicinal products metabolised by CYP450 isoforms.
Sildenafil metabolism is principally mediated by the cytochrome P450(CYP) isoforms 3A4(major route) and 2C9 minor route.
CYP isoforms 2E1, 1A2, 2B6, 2C8, and 2C19 are involved to a lesser extent and isoforms 2D6 and 2C9 are not involved in the metabolism of lomitapide.
In vitro evaluation indicated that trifluridine andFTY had no inductive effect on human CYP isoforms see section 5.2.
Adefovir did not influence any of the common CYP isoforms known to be involved in human drug metabolism and is excreted renally.
In vitro studies haveshown that brivaracetam exhibits little or no inhibition of CYP450 isoforms except for CYP2C19.
Ritonavir has a high affinity for several cytochrome P450(CYP) isoforms and may inhibit oxidation with the following ranked order: CYP3A4> CYP2D6.
In vitro experiments indicate that telavancin will not affect the clearance of medicinal products metabolised by CYP isoforms 1A2, 2C9, 2C19 and 2D6.
Concurrent use of substances which are metabolised by CYP450 isoforms may result in higher or lower plasma levels of either masitinib or those substances.
Neither emtricitabine nor tenofovir inhibited in vitro drug metabolism mediated by any of the major human CYP isoforms involved in drug biotransformation.
Drug-drug interactions involving the major CYP450 and UGT isoforms with empagliflozin and concomitantly administered substrates of these enzymes are therefore considered unlikely.
Emtricitabine did not inhibit in vitro drug metabolism mediated by any of the major human CYP isoforms involved in drug biotransformation.
In vitro studies indicated that trifluridine, tipiracil hydrochloride and5-[trifluoromethyl] uracil(FTY) did not inhibit the activity of human cytochrome P450(CYP) isoforms.
Studies have confirmed that tadalafil does not inhibit orinduce CYP450 isoforms, including CYP3A4, CYP1A2, CYP2D6, CYP2E1, CYP2C9 and CYP2C19.
Multiple-dose administration of elbasvir orgrazoprevir is unlikely to induce the metabolism of medicinal products metabolised by CYP isoforms based on in vitro data.
Dutasteride powder is a synthetic 4-azasteroid compound that is a selective inhibitor of both the type 1 andtype 2 isoforms of steroid 5 alpha-reductase used to treat benign prostatic hyperplasia(BPH) in men with an enlarged prostate.