Sta Znaci ISOFORMS na Hrvatskom - Hrvatski Prijevod

• izoforme
• izooblika
• izoformi

Primjeri korištenja Isoforms na Engleski i njihovi prijevodi na Hrvatskom

Inhibition of CYP isoforms.
Inhibicija izooblika CYP.

There are two isoforms of COX, COX-1, and COX-2.
COX ima dvije izoforme, COX-1 i COX-2.

The cyclo-oxygenase enzyme(COX) is present in two isoforms.
Enzim ciklooksigenaza(COX) prisutan je u dva izoforma.

Two isoforms, COX-1 and COX-2, have been identified.
Utvrđena su dva izooblika, COX-1 i COX-2.

These receptors exist in 2 isoforms, PR-A and PR-B.
Ti receptori postoje u 2 izoformama, PR-A i PR-B.

In human liver microsomes, abacavir did not inhibit cytochrome P450 isoforms.
Abakavir nije inhibirao izoforme citokroma P450 u mikrosomima ljudske jetre.

In vitro results indicate that different CYP isoforms are able to catalyse the N-dealkylation of rotigotine.
In vitro rezultati ukazuju da različite CYP izoforme mogu kataliziratiN- dealkilaciju rotigotina.

Based on in vitro studies, empagliflozin does not inhibit, inactivate, or induce CYP450 isoforms.
Na temelju in vitro ispitivanja empagliflozin ne inhibira, ne inaktivira niti ne inducira izoforme CYP450.

From the recombinant CYP isoforms investigated in vitro CYP1A1 catalysed formation of riociguat's main metabolite most effectively.
Od rekombinantnih izooblika CYP ispitivanih in vitro, CYP1A1 najučinkovitije je katalizirao stvaranje glavnog metabolita riocigvata.

The protein occurs in the plasma in 2 main isoforms, ApoB48 and ApoB100.
Protein se nalazi u krvi čovjeka u dvije glavne izofrome, kao APOB48 i APOB100.

In vitro study results demonstrate that ingenol mebutate does not inhibit or induce human cytochrome P450 isoforms.
Rezultati ispitivanja in vitro pokazuju da ingenol mebutat ne inhibira niti inducira izoforme ljudskog citokroma P450.

Sildenafil metabolism is principally mediated by the cytochrome P450(CYP) isoforms 3A4(major route) and 2C9 minor route.
Sildenafil se prvenstveno metabolizira posredstvom izoformi(CYP) 3A4(glavni put) i 2C9(manji put) citokroma P450.

In vitro studies demonstrated that neither oseltamivir nor the active metabolite is a substrate for, or an inhibitor of, the major cytochrome P450 isoforms.
Ispitivanja in vitro pokazala su da ni oseltamivir ni aktivni metabolit nisu supstrati ili inhibitori glavnih izoformi citokroma P450.

It is unlikely that atosiban inhibits hepatic cytochrome P450 isoforms in humans see section 4.5.
Malo je vjerojatno da atosiban inhibira hepatalne izooblike citokroma P450 u ljudi vidjeti dio 4.5.

Tadalafil is not expected to cause clinically significant inhibition or induction of the clearance of medicinal products metabolised by CYP450 isoforms.
Ne očekuje se da bi tadalafil mogao izazvati klinički značajnu inhibiciju ili indukciju klirensa lijekova koje metaboliziraju izoforme CYP450.

Sildenafil metabolism is principally mediated by the cytochrome P450(CYP) isoforms 3A4(major route) and 2C9 minor route.
Metabolizam sildenafila uglavnom je posredovan citokromom P450(CYP) izoformama 3A4(glavni put) i 2C9 sporedni put.

CYP isoforms 2E1, 1A2, 2B6, 2C8, and 2C19 are involved to a lesser extent and isoforms 2D6 and 2C9 are not involved in the metabolism of lomitapide.
Izoforme CYP-a 2E1, 1A2, 2B6, 2C8 i 2C19 uključene su u manjem opsegu a izoforme 2D6 i 2C9 nisu uključene u metabolizam lomitapida.

In vitro evaluation indicated that trifluridine and FTY had no inductive effect on human CYP isoforms see section 5.2.
In vitro ispitivanja ukazuju da trifluridin i FTY nemaju indukcijski učinak na ljudske CYP izoforme vidjeti dio 5.2.

Adefovir did not influence any of the common CYP isoforms known to be involved in human drug metabolism and is excreted renally.
Adefovir nije utjecao na neku od čestih CYP izoformi za koje se zna da su uključene u metabolizam lijeka u ljudi te se izlučuje renalnim putem.

In vitro studies have shown that brivaracetam exhibits little or no inhibition of CYP450 isoforms except for CYP2C19.
Ispitivanja in vitro pokazala su da brivaracetam ostvaruje neznatnu ili nikakvu inhibiciju izooblika enzima CYP450 osim za enzim CYP2C19.

Ritonavir has a high affinity for several cytochrome P450(CYP) isoforms and may inhibit oxidation with the following ranked order: CYP3A4> CYP2D6.
Ritonavir ima visok afinitet za nekoliko izoformi citokroma P450(CYP) i može inhibirati oksidaciju ovim slijedom prema jačini: CYP3A4> CYP2D6.

In vitro experiments indicate that telavancin will not affect the clearance of medicinal products metabolised by CYP isoforms 1A2, 2C9, 2C19 and 2D6.
In vitro eksperimenti pokazuju da telavancin neće imati utjecaj na klirens lijekova koje metabolizira CYP izooblika 1A2, 2C9, 2C19 i 2D6.

Concurrent use of substances which are metabolised by CYP450 isoforms may result in higher or lower plasma levels of either masitinib or those substances.
Istodobna primjena tvari koje se metaboliziraju putem izooblika CYP450 može dovesti do viših ili nižih razina masitiniba ili tih tvari u plazmi.

Neither emtricitabine nor tenofovir inhibited in vitro drug metabolism mediated by any of the major human CYP isoforms involved in drug biotransformation.
Ni emtricitabin niti tenofovir nisu inhibirali in vitro metabolizam lijekova koji se biotransformiraju pomoću bilo kojeg od važnijih CYP izoformi u ljudi.

Drug-drug interactions involving the major CYP450 and UGT isoforms with empagliflozin and concomitantly administered substrates of these enzymes are therefore considered unlikely.
Stoga se interakcije među lijekovima koje uključuju glavne izoforme enzima CYP450 i UGT s empagliflozinom i istodobno primijenjenim supstratima tih enzima ne smatraju vjerojatnim.

Emtricitabine did not inhibit in vitro drug metabolism mediated by any of the major human CYP isoforms involved in drug biotransformation.
Emtricitabin nije inhibirao in vitro metabolizam lijeka posredovan bilo kojom od glavnih izoformi ljudskog CYP-a koje su dio biotransformacije lijeka.

In vitro studies indicated that trifluridine, tipiracil hydrochloride and 5-[trifluoromethyl] uracil(FTY) did not inhibit the activity of human cytochrome P450(CYP) isoforms.
In vitro ispitivanja ukazuju da trifluridin, tipiracilklorid i5-[trifluorometil] uracil(FTY) ne inhibiraju aktivnost ljudskih izoformi citokroma P450 CYP.

Studies have confirmed that tadalafil does not inhibit or induce CYP450 isoforms, including CYP3A4, CYP1A2, CYP2D6, CYP2E1, CYP2C9 and CYP2C19.
Ispitivanja su potvrdila da tadalafil ne inhibira niti inducira izoforme a CYP450, uključujući CYP3A4, CYP1A2, CYP2D6, CYP2E1, CYP2C9 i CYP2C19.

Multiple-dose administration of elbasvir or grazoprevir is unlikely to induce the metabolism of medicinal products metabolised by CYP isoforms based on in vitro data.
Prema podacima in vitro, nije vjerojatno da će primjena višestrukih doza elbasvira ili grazoprevira inducirati metabolizam lijekova koji se metaboliziraju putem izoformi CYP enzima.

Dutasteride powder is a synthetic 4-azasteroid compound that is a selective inhibitor of both the type 1 and type 2 isoforms of steroid 5 alpha-reductase used to treat benign prostatic hyperplasia(BPH) in men with an enlarged prostate.
Dutasteridni prah je sintetski 4-azasteroidni spoj koji je selektivni inhibitor i tipa 1 i tipa 2 izoforme steroidne 5 alfa-reduktaze koji se koriste za liječenje benigne hiperplazije prostate(BPH) kod muškaraca s povećanom prostatom.