Examples of using Platelet function in English and their translations into Romanian
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Platelet function is restored within 60 minutes of stopping infusion.
Medicinal products that inhibit serotonin uptake may lead to reduced platelet function.
Since iloprost inhibits platelet function its use with the following substances may enhance iloprost- mediated platelet inhibition, thereby increasing the risk of bleeding.
Nitric oxide: since both medicinal products inhibit platelet function, their combination may in.
Pharmacogenetics: In patients who are poor CYP2C19 metabolisers, clopidogrel at recommended doses forms less of the active metabolite of clopidogrel andhas a smaller effect on platelet function.
Caution is advised in patients taking anticoagulants and/ ormedicinal products known to affect platelet function, and in patients with known bleeding tendencies.
TP plays a role in platelet function; however, therapeutic doses of laropiprant had no clinically relevant effect on bleeding time and collagen-induced platelet aggregation(see section 4.5).
Caution should be exercised if patients are required to take medicinal products that inhibit platelet function or anticoagulants.
Medicinal products that affect coagulation or those that alter platelet function(e.g. ticlopidine, clopidogrel, LMWH) may increase the risk of bleeding prior to, during or after tenecteplase therapy.
Irrespective of dose, following cessation of the infusion,blood levels decrease rapidly and platelet function returns to normal within one hour.
Platelet inhibition was readily reversed, with a return of platelet function towards baseline(> 50% platelet aggregation) 4 hours after stopping a continuous infusion of 2.0 microgram/kg/min.
Patients were excluded from participation in SPRYCEL clinical trials if they took medicinal products that inhibit platelet function or anticoagulants.
The use of new intravenous“super aspirins”,which alter platelet function at a site different from the site of aspirin-inhibition, have dramatically reduced the incidence of thrombosis after balloon angioplasty and stenting.
If bleeding occurs appropriate supportive measures should be taken,which may include stopping the medicinal product so platelet function can return.
Caution is advised in patients taking anticoagulants and/or medicinal products known to affect platelet function(e.g. NSAIDs or acetylsalicylic acid(ASA)), and in patients with known bleeding tendencies.
In young subjects, Dynastat 40 mg twice daily had no clinically significant effect on acetylsalicylic acid- mediated inhibition of platelet function(see section 4.5).
Heparin, vitamin K antagonists andmedicinal product that alter platelet function(such as acetylsalicylic acid, dipyridamole and abciximab) may increase the risk of bleeding if administered prior to, during or after reteplase therapy.
Concomitant treatment with coumarin derivatives(vitamin K antagonists) anddrugs that affect platelet function may also increase the risk of bleeding.
Caution is advised in patients taking anticoagulants and/or medicinal products known to affect platelet function[e.g. atypical antipsychotics and phenothiazines, most tricyclic antidepressants, non-steroidal anti-inflammatory drugs(NSAIDs), acetylsalicylic acid(ASA)](see section 4.5) and in patients with known bleeding tendencies/disorders.
If the patient requires semi-elective surgery,stop the eptifibatide infusion at an appropriate time to allow time for platelet function to return towards normal.
As with other anticoagulants desirudin should be used with caution in conjunction with medicinal products which affect platelet function these medicinal products include: acetylsalicylic acid and NSAIDs, ticlopidine and clopidogrel, glycoprotein IIb/ IIIa antagonists(abciximab, eptifibatide, tirofiban) and iloprost.
At the doses recommended for use in the treatment of essential thrombocythaemia,anagrelide may potentiate the effects of other medicinal products that inhibit or modify platelet function e.g. acetylsalicylic acid.
Caution is advisedin patients taking Votubia, particularly during concomitant use with active substances known to affect platelet function or that can increase the risk of haemorrhage as well as in patients with a history of bleeding disorders.
Ticagrelor has been documented to augment the following adenosine-induced effects in healthy subjects and in patients with ACS: vasodilation(measured by coronary blood flow increases in healthy volunteers and ACS patients; headache),inhibition of platelet function(in human whole blood in vitro) and dyspnoea.
Iloprost can inhibit platelet function and its use with anticoagulants(such as heparin, coumarin-type anticoagulants) or other inhibitors of platelet aggregation(such as acetylsalicylic acid, non-steroidal anti-inflammatory medicinal products, ticlopidine, clopidogrel and glycoprotein IIb/ IIIa antagonists: abciximab, eptifibatide and tirofiban) may increase the risk of bleeding.
Since platelets participate in the initiation and/or evolution of thrombotic complications of atherosclerotic disease, inhibition of platelet function has been shown to reduce the risk of CV events such as death, MI or stroke.
In typical circumstances, fibrinogen is measured in citrated plasma samples in the laboratory,however the analysis of whole-blood samples by use of thromboelastometry(platelet function is inhibited with cytochalasin D) is also possible.
As expected for a prostacyclin, iloprost produced haemodynamic effects(vasodilatation, reddening of skin, hypotension,inhibition of platelet function, respiratory distress) and general signs of intoxication such as apathy, gait disturbances, and postural changes.
Due to the irreversible binding, platelets exposed are affected for the remainder of their lifespan(approximately 7- 10 days) and recovery of normal platelet function occurs at a rate consistent with platelet turnover.
Since platelets participate in the initiation and/ or evolution of thrombotic complications of atherosclerotic disease, inhibition of platelet function can result in the reduction of the rate of cardiovascular events such as death, myocardial infarction, or stroke.