Примери за използване на Isoforms на Английски и техните преводи на Български
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Inhibition of CYP isoforms.
Two isoforms, COX-1 and COX-2.
There are two isoforms of COX.
CYP isoforms selective substrates.
MMAE does not inhibit other isoforms.
There are two isoforms of COX, COX-1, and COX-2.
Ertugliflozin glucuronides had no effect on these isoforms.
Isoforms, in this case, are different forms of a protein coded for by the same gene.
In human liver microsomes, abacavir did not inhibit cytochrome P450 isoforms.
The UGT isoforms responsible for the phase II conjugation of cannabidiol are UGT1A7, UGT1A9 and UGT2B7.
Production of the primary metabolite, ucb L057,is not supported by liver cytochrome P450 isoforms.
In vitro results indicate that different CYP isoforms are able to catalyse the N-dealkylation of rotigotine.
Based on in vitro studies, empagliflozin does not inhibit, inactivate, orinduce CYP450 isoforms.
Studies have confirmed that tadalafil does not inhibit orinduce CYP450 isoforms, including CYP3A4, CYP1A2, CYP2D6, CYP2E1.
In vitro study results demonstrate that ingenol mebutatedoes not inhibit or induce human cytochrome P450 isoforms.
The role of superoxide dismutase isoforms in coronary artery disease and acute coronary syndromes- 48, 2012,№ 4, 19-26.
Oritavancin was found to be a nonspecific, weak inhibitor(CYP2C9 and CYP2C19) or a weak inducer(CYP3A4 andCYP2D6) of several CYP isoforms.
Donkey milk lysozyme presents two isoforms that differ in three amino acid substitutions at position 48, 52 and 61[29].
In vitro evaluation indicated that trifluridine, tipiracil hydrochloride andFTY had no inductive effect on human CYP isoforms(see section 5.2).
In vitro, multiple cytochrome P-450 isoforms including CYP3A, CYP2C19/C9 and CYP2D6 are responsible for metabolism of nelfinavir.
Therefore, clearance of tigecycline is not expected to be affected by active substances that inhibit orinduce the activity of the CYP450 isoforms.
From the recombinant CYP isoforms investigated in vitro CYP1A1 catalysed formation of riociguat's main metabolite most effectively.
Studies have confirmed that tadalafil does not inhibit orinduce CYP450 isoforms, including CYP3A4, CYP1A2, CYP2D6, CYP2E1, CYP2C9 and CYP2C19.
In vitro studies demonstrated that neither oseltamivir nor the active metabolite is a substrate for, or an inhibitor of,the major cytochrome P450 isoforms.
Ritonavir has a high affinity for several cytochrome P450(CYP) isoforms and may inhibit oxidation with the following ranked order: CYP3A4> CYP2D6.
In vitro studies have determined that daptomycin does not inhibit orinduce the activities of clinically significant human CYP isoforms(1A2, 2A6, 2C9, 2C19, 2D6, 2E1, 3A4).
The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative….
In vitro studies indicated that trifluridine, tipiracil hydrochloride and 5-[trifluoromethyl]uracil(FTY) did not inhibit the activity of human cytochrome P450(CYP) isoforms.
Metabolism: In vitro studies demonstrated that multiple cytochrome P-450 isoforms including CYP3A, CYP2C19/C9 and CYP2D6 are responsible for the metabolism of nelfinavir.
The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA.