Примери коришћења Isoforms на Енглеском и њихови преводи на Српски
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Conventional(c)PKCs contain the isoforms α, βI, βII, and γ.
The resulting different mRNAs may be translated into different protein isoforms;
In biochemistry, isozymes(or isoenzymes)are isoforms(closely related variants) of enzymes.
Many of these isoforms are rare haplotypes that are usually associated with a state of disease.
Previous reports have identified as many as eight splice variants,which are translated into seven isoforms of the protein.
Several isoforms of these enzymes exist, leading to a highly complex synthesis process.[13].
Novel(n)PKCs include the δ, ε, η,and θ isoforms, and require DAG, but do not require Ca2+ for activation.
Alternative splicing of the GNRHR gene, GNRHR,results in multiple transcript variants encoding different isoforms.
There are two splice isoforms of RGS9 with quite different properties and patterns of expression.
The Human Genome Project has revealed that more than a dozen other calpain isoforms exist, some with multiple splice variants.
The two isoforms of Bcl-2, Isoform 1, also known as 1G5M, and Isoform 2, also known as 1G5O/1GJH, exhibit a similar fold.
Neuromedin U, like many neuroactive peptides,is amidated at the C-terminus, and all isoforms have identical C-terminal heptapeptides.
There are four main isoforms expressed in humans(family 1, see chart below): MT1(subtypes A, B, E, F, G, H, L, M, X), MT2, MT3, and MT4.
Biochemically, the insulin receptor is encoded by a single gene INSR,from which alternate splicing during transcription results in either IR-A or IR-B isoforms.
Since many isoforms of PKC are also activated by increases in intracellular Ca2+, both these pathways can also converge on each other to signal through the same secondary effector.
The primary effectors of Gβγ are various ion channels, such as G-protein-regulated inwardly rectifying K+ channels(GIRKs), P/Q- and N-type voltage-gated Ca2+ channels,as well as some isoforms of AC and PLC, along with some phosphoinositide-3-kinase(PI3K) isoforms. .
Characterization of isoforms and function analysis of glucocorticoid receptor expressed in yeast and mammalian cells"BSc: Molecular Biology and Physiology, Faculty of Biology, University of Belgrade, 1995.
Calcineurin is a heterodimer of a 61-kD calmodulin-binding catalytic subunit, calcineurin A and a 19-kD Ca2+-binding regulatory subunit, calcineurin B. There are three isozymes of the catalytic subunit, each encoded by a separate gene(PPP3CA, PPP3CB,and PPP3CC) and two isoforms of the regulatory, also encoded by separate genes(PPP3R1, PPP3R2).
The isoforms with 40 and 42 amino acids(Aβ40/42) are the main constituents of amyloid plaques in the brains of Alzheimer's disease patients. β-Amyloid is formed by proteolysis of amyloid precursor protein(APP).
These isoforms vary in their ligand-binding properties and kinase domains, however all share the common extracellular region composed of three immunoglobulin(Ig)-like domains(D1-D3), and thus belong to the immunoglobulin superfamily.
Bcl- 2 Isoform 1.
It is an isoform of Beta-Thromboglobulin or Pro-Platelet basic protein(PPBP).
On the other hand, circadian phenotypes of RORγ-/- mice in tissues where the RORγt isoform is expressed in minute amounts argues for the expression of functional RORγ isoform.
Each receptor isoform has ten splice variants: four for alpha, four for beta, and two for gamma.
In addition, a conformation that preferably activates one isoform of Gα may activate another if the preferred is less available.
The enol forms of oxaloacetic acid are particularly stable, so much so thatthe two tautomer have different melting points(152 °C for the cis isoform and 184 °C for the trans isoform).
Consistent with this, the main phenotypes identified in RORγ-/- knockout mice(where neither isoform is expressed) are those associated with RORγt immune system function and an isoform specific RORγt knockout displayed a phenotype identical to the RORγ-/- knockout.
In photosynthesizing tissues, it uses an isoform of ferredoxin(Fd1) that is reduced by PSI while in the root it uses a form of ferredoxin(Fd3) that has a less negative midpoint potential and can be reduced easily by NADPH.
There are two TR-α receptor splice variants encoded by the THRA gene and two TR-β isoform splice variants encoded by the THRB gene: TR-α1(widely expressed and especially high expression in cardiac and skeletal muscles) TR-α2(homologous with viral oncogene c-erb-A, also widely expressed but unable to bind hormone) TR-β1(predominately expressed in brain, liver and kidney) TR-β2(expression primarily limited to the hypothalamus and pituitary) Certain mutations in the thyroid hormone receptor are associated with thyroid hormone resistance.
No single isoform appears to have a predominant role.